ERK-IN-3
Modify Date: 2025-08-26 17:40:30
ERK-IN-3 structure
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Common Name | ERK-IN-3 | ||
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| CAS Number | 2055597-12-9 | Molecular Weight | 473.93 | |
| Density | N/A | Boiling Point | N/A | |
| Molecular Formula | C22H25ClFN7O2 | Melting Point | N/A | |
| MSDS | N/A | Flash Point | N/A | |
Use of ERK-IN-3ERK-IN-3 is a potent and oral inhibitor of ERK. ERK-IN-3 inhibits ERK1/2 with low single-digit nM IC50 values. ERK-IN-3 has the potential to be used to study cancers driven by RAS mutations.[1]. |
| Name | ERK-IN-3 |
|---|
| Description | ERK-IN-3 is a potent and oral inhibitor of ERK. ERK-IN-3 inhibits ERK1/2 with low single-digit nM IC50 values. ERK-IN-3 has the potential to be used to study cancers driven by RAS mutations.[1]. |
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| Related Catalog | |
| Target |
ERK1 ERK2 |
| In Vitro | ERK-IN-3 inhibits the phosphorylation of ERK1/2 substrates such as RSK1, FRA1, and Elk1 in various cell lines[1]. ERK-IN-3 showes single-digit nanomolar antiproliferative activity that is selective for MAPK-pathway dependent cancer cell lines[1]. |
| In Vivo | ERK-IN-3 (daily p.o.) inhibits tumor growth in multiple BRAF and KRAS mutant xenograft models in mice and was well tolerated at efficacious doses[1]. |
| References |
| Molecular Formula | C22H25ClFN7O2 |
|---|---|
| Molecular Weight | 473.93 |