2743576-55-6
2743576-55-6 structure
- Name: ERK-IN-2 free base
- Chemical Name: ERK-IN-2 free base
- CAS Number: 2743576-55-6
- Molecular Formula: C16H17N5O2
- Molecular Weight: 311.34
- Catalog: Signaling Pathways MAPK/ERK Pathway ERK
- Create Date: 2022-11-21 11:33:21
- Modify Date: 2024-02-03 09:19:24
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ERK-IN-2 free base is a ERK2 inhibitor with an IC50 value of 1.8 nM. ERK-IN-2 free base might lead to off-target toxicity and/or off-target activity at dose >10 μM[1].
| Name | ERK-IN-2 free base |
|---|
| Description | ERK-IN-2 free base is a ERK2 inhibitor with an IC50 value of 1.8 nM. ERK-IN-2 free base might lead to off-target toxicity and/or off-target activity at dose >10 μM[1]. |
|---|---|
| Related Catalog | |
| Target |
ERK2:1.8 nM (IC50) |
| In Vitro | ERK-IN-2 (ERKi) inhibits RSK phosphorylation with an IC50 of 280 nM[1]. ERK-IN-2 (ERKi, 1 μM) inhibits cell proliferation in cancer cell lines, with IC50 values of 214 nM; 305 nM; 91 nM and 201 nM for A375SM cell, SK-MEL 30 cell; Colo 205 cell and Lovo cell, respectively[1]. |
| In Vivo | ERK-IN-2 (1 mpk, p.o.; or 0.5 mpk, i.v.; rat) shows a t1/2 of 0.4 h, and F% of 13%[1]. |
| References |
| Molecular Formula | C16H17N5O2 |
|---|---|
| Molecular Weight | 311.34 |