CDK12-IN-3

Modify Date: 2024-02-18 17:26:37

CDK12-IN-3 structure	Common Name	CDK12-IN-3
	CAS Number	2220184-50-7	Molecular Weight	470.52
	Density	N/A	Boiling Point	N/A
	Molecular Formula	C₂₃H₂₈F₂N₈O	Melting Point	N/A
	MSDS	N/A	Flash Point	N/A

Use of CDK12-IN-3

CMPD 7 is a potent and selective CDK12 inhibitor with an IC50 of 491 nM in enzymatic assay.

Name	CMPD 7

Description	CMPD 7 is a potent and selective CDK12 inhibitor with an IC50 of 491 nM in enzymatic assay.
Related Catalog	Research Areas >> Cancer
Target	IC50: 491 nM (CDK12)[1]
In Vitro	CMPD 7 is a highly selective CDK12 inhibitor profiled across a panel of 352 kinases at 0.1 µM. CMPD 7 shows potent inhibition of phosphorylation of Ser2 on the CTD repeat domain of RNA Pol II as well as growth inhibition of OV90 cells and acute cytotoxicity to THP1 cells[1].
References	[1]. Johannes JW, et al. Structure-Based Design of Selective Noncovalent CDK12 Inhibitors. ChemMedChem. 2018 Feb 6;13(3):231-235.

Molecular Formula	C₂₃H₂₈F₂N₈O
Molecular Weight	470.52