CDK12-IN-6

Modify Date: 2024-01-08 22:13:01

CDK12-IN-6 structure	Common Name	CDK12-IN-6
	CAS Number	2651196-71-1	Molecular Weight	425.44
	Density	N/A	Boiling Point	N/A
	Molecular Formula	C₂₀H₂₁F₂N₉	Melting Point	N/A
	MSDS	N/A	Flash Point	N/A

Use of CDK12-IN-6

CDK12-IN-6, a pyrazolotriazine, is a potent CDK12 inhibitor with an IC50 of 1.19 μM at high ATP (2 mM). CDK12-IN-6 has no effect on CDK2/Cyclin E (IC50>20 μM) and CDK9/Cyclin T1 (IC50>20 μM) at high ATP (2 mM) (WO2021116178A1)[1].

Name	CDK12-IN-6

Description	CDK12-IN-6, a pyrazolotriazine, is a potent CDK12 inhibitor with an IC50 of 1.19 μM at high ATP (2 mM). CDK12-IN-6 has no effect on CDK2/Cyclin E (IC50>20 μM) and CDK9/Cyclin T1 (IC50>20 μM) at high ATP (2 mM) (WO2021116178A1)[1].
Related Catalog	Research Areas >> Cancer Signaling Pathways >> Cell Cycle/DNA Damage >> CDK
Target	CDK12:1.19 μM (IC50) CDK2/cyclinE:>20 μM (IC50) CDK9/cyclinT1:>20 μM (IC50)
In Vitro	CDK12-IN-6 (Example 174) inhibits BRCA1 MRNA expression in MDA-MB-231 cells (IC50=0.872 nM) and has no effect on CAL-120 cells[1]. CDK12-IN-6 has antproliferative activity in MDA-MB-231 cells (IC50=2.19 nM) and CAL-120 cells (IC50=1 nM)[1]. CDK12-IN-6 has a inhibition IC50 CDK12 high ATP to Degradation DC50 CDK12 ratio of 1851[1].
References	[1]. Kai Thede, et al. Pyrazolotriazines. WO2021116178A1.

Molecular Formula	C₂₀H₂₁F₂N₉
Molecular Weight	425.44

DC Chemicals Limited
China
Product Name: CDK12-IN-6
Price: ￥Inquiry/1g
Purity: 98.9%
Stocking Period: 1 Day
Contact: Tony Cao

Get all suppliers and price by the below link:

CDK12-IN-6 suppliers

CDK12-IN-6 price

CDK12-IN-6

Use of CDK12-IN-6

Names

CDK12-IN-6 Biological Activity

Chemical & Physical Properties