CDK12-IN-5

Modify Date: 2024-01-20 15:32:53

CDK12-IN-5 structure	Common Name	CDK12-IN-5
	CAS Number	2651200-35-8	Molecular Weight	454.36
	Density	N/A	Boiling Point	N/A
	Molecular Formula	C₁₈H₁₅F₅N₈O	Melting Point	N/A
	MSDS	N/A	Flash Point	N/A

Use of CDK12-IN-5

CDK12-IN-5, a pyrazolotriazine, is a potent CDK12 inhibitor with an IC50 of 23.9 nM at high ATP (2 mM). CDK12-IN-5 has no effect on CDK2/Cyclin E (IC50=173 μM) and CDK9/Cyclin T1 (IC50=127 μM) at high ATP (2 mM) (WO2021116178A1)[1].

Name	CDK12-IN-5

Description	CDK12-IN-5, a pyrazolotriazine, is a potent CDK12 inhibitor with an IC50 of 23.9 nM at high ATP (2 mM). CDK12-IN-5 has no effect on CDK2/Cyclin E (IC50=173 μM) and CDK9/Cyclin T1 (IC50=127 μM) at high ATP (2 mM) (WO2021116178A1)[1].
Related Catalog	Research Areas >> Cancer Signaling Pathways >> Cell Cycle/DNA Damage >> CDK
Target	CDK12:23.9 nM (IC50) CDK2/cyclinE:173 μM (IC50) CDK9/cyclinT1:127 μM (IC50)
In Vitro	CDK12-IN-5 (Example 426) inhibits BRCA1 MRNA expression in MDA-MB-231 cells (IC50=3.23 nM) and has no effect on CAL-120 cells[1]. CDK12-IN-5 has antproliferative activity in MDA-MB-231 cells (IC50=4.19 nM) and CAL-120 cells (IC50=3.57 nM)[1]. CDK12-IN-5 has a inhibition IC50 CDK12 high ATP to Degradation DC50 CDK12 ratio of 32[1].
References	[1]. Kai Thede, et al. Pyrazolotriazines. WO2021116178A1.

Molecular Formula	C₁₈H₁₅F₅N₈O
Molecular Weight	454.36

DC Chemicals Limited
China
Product Name: CDK12-IN-5
Price: ￥Inquiry/1g
Purity: 98.9%
Stocking Period: 1 Day
Contact: Tony Cao

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