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CDK12-IN-3

Names

[ CAS No. ]:
2220184-50-7

[ Name ]:
CDK12-IN-3

Biological Activity

[Description]:

CMPD 7 is a potent and selective CDK12 inhibitor with an IC50 of 491 nM in enzymatic assay.

[Related Catalog]:

Research Areas >> Cancer

[Target]

IC50: 491 nM (CDK12)[1]


[In Vitro]

CMPD 7 is a highly selective CDK12 inhibitor profiled across a panel of 352 kinases at 0.1 µM. CMPD 7 shows potent inhibition of phosphorylation of Ser2 on the CTD repeat domain of RNA Pol II as well as growth inhibition of OV90 cells and acute cytotoxicity to THP1 cells[1].

[References]

[1]. Johannes JW, et al. Structure-Based Design of Selective Noncovalent CDK12 Inhibitors. ChemMedChem. 2018 Feb 6;13(3):231-235.


[Related Small Molecules]

Abemaciclib(LY2835219) | Ribociclib (LEE011) | Dinaciclib (SCH727965) | THZ1 2HCl | Roscovitine (CYC202) | THZ531 | RO-3306 | Flavopiridol | NVP 2 | BAY-1143572 Racemate | CYC-065 | AZD5438 | BIO | Kenpaullone | SNS-032 (BMS-387032)

Chemical & Physical Properties

[ Molecular Formula ]:
C23H28F2N8O

[ Molecular Weight ]:
470.52

Related Compounds