RO-3306
Names
[ CAS No. ]:
872573-93-8
[ Name ]:
RO-3306
[Synonym ]:
4(5H)-Thiazolone, 5-(6-quinolinylmethylene)-2-[(2-thienylmethyl)amino]-, (5Z)-
(5Z)-5-(quinolin-6-ylmethylidene)-2-[(thiophen-2-ylmethyl)amino]-1,3-thiazol-4(5H)-one
(5Z)-5-(quinolin-6-ylmethylidene)-2-(thiophen-2-ylmethylamino)-1,3-thiazol-4-one
(5Z)-5-(6-Quinolinylmethylene)-2-[(2-thienylmethyl)amino]-1,3-thiazol-4(5H)-one
Biological Activity
[Description]:
[Related Catalog]:
[Target]
CDK1:20 nM (Ki)
CDK1/cyclinB1:35 nM (Ki)
CDK1/cyclin A:110 nM (Ki)
CDK2/cyclinE:340 nM (Ki)
PKCδ:318 nM (Ki)
SGK:497 nM (Ki)
ERK:1980 nM (Ki)
[In Vitro]
[Kinase Assay]
[References]
[Related Small Molecules]
Chemical & Physical Properties
[ Density]:
1.4±0.1 g/cm3
[ Boiling Point ]:
569.1±60.0 °C at 760 mmHg
[ Molecular Formula ]:
C18H13N3OS2
[ Molecular Weight ]:
351.445
[ Flash Point ]:
298.0±32.9 °C
[ Exact Mass ]:
351.049988
[ PSA ]:
111.38000
[ LogP ]:
3.24
[ Appearance of Characters ]:
white to light brown
[ Vapour Pressure ]:
0.0±1.6 mmHg at 25°C
[ Index of Refraction ]:
1.746
[ Storage condition ]:
2-8°C
[ Water Solubility ]:
DMSO: soluble5mg/mL, clear
MSDS
Safety Information
[ RIDADR ]:
NONH for all modes of transport
Articles
Proc. Natl. Acad. Sci. U. S. A. 112 , 5875-82, (2015)
Mitosis is commonly thought to be associated with reduced cap-dependent protein translation. Here we show an alternative control mechanism for maintaining cap-dependent translation during mitosis reve...
JNK2 controls fragmentation of the Golgi complex and the G2/M transition through phosphorylation of GRASP65.J. Cell Sci. 128 , 2249-60, (2015)
In mammalian cells, the Golgi complex is composed of stacks that are connected by membranous tubules. During G2, the Golgi complex is disassembled into isolated stacks. This process is required for en...
A Cholesterol-Dependent Endocytic Mechanism Generates Midbody Tubules During Cytokinesis.Traffic 16 , 1174-92, (2015)
Cytokinesis is the final stage of cell division and produces two independent daughter cells. Vesicles derived from internal membrane stores, such as the Golgi, lysosomes, and early and recycling endos...