RO 20-1724

Names

[ Name ]:
RO 20-1724

[Synonym ]:
MFCD00077397
4-[(3-butoxy-4-methoxyphenyl)methyl]-2-imidazolidinone

Biological Activity

[Description]:

Ro 20-1724 (Ro 20-174) is a potent inhibitor of cAMP-specific phosphodiesterase (PDE4/PDE IV) with a Ki of 1930 nM. Neuroprotective effect[1][2].

[Related Catalog]:

Signaling Pathways >> Metabolic Enzyme/Protease >> Phosphodiesterase (PDE)

Research Areas >> Neurological Disease

[Target]

PDE4:1930 nM (Ki)

[In Vivo]

Ro 20-1724 (125, 250 and 500 μg/kg; i.p.; 21 days following first i.c.v. streptozotocin administration; 200-250 g adult (3-5 months old) male albino Wistar rats) significantly attenuated streptozotocin induced cognitive deficit and oxidative stress[2].

[References]

[1]. Brackeen MF, et al. Design and synthesis of conformationally constrained analogues of 4-(3-butoxy-4-methoxybenzyl)imidazolidin-2-one (Ro 20-1724) as potent inhibitors of cAMP-specific phosphodiesterase. J Med Chem. 1995;38(24):4848-4854.

[2]. Sharma V, et al. Neuroprotective effect of RO-20-1724-a phosphodiesterase4 inhibitor against intracerebroventricular streptozotocin induced cognitive deficit and oxidative stress in rats. Pharmacol Biochem Behav. 2012;101(2):239-245.

Chemical & Physical Properties

[ Density]:
1.099 g/cm3

[ Boiling Point ]:
483.8ºC at 760 mmHg

[ Molecular Formula ]:
C₁₅H₂₂N₂O₃

[ Molecular Weight ]:
278.35

[ Flash Point ]:
246.4ºC

[ Exact Mass ]:
278.16300

[ PSA ]:
59.59000

[ LogP ]:
2.75560

[ Vapour Pressure ]:
1.62E-09mmHg at 25°C

[ Index of Refraction ]:
1.521

[ Storage condition ]:
Store at RT

[ Water Solubility ]:
ethanol: 7 mg/mL

MSDS

Click to get detail MSDS

Safety Information

[ Personal Protective Equipment ]:
dust mask type N95 (US);Eyeshields;Gloves

[ Hazard Codes ]:
Xi: Irritant;

[ Risk Phrases ]:
R36/37/38

[ Safety Phrases ]:
S26-S36

[ RIDADR ]:
NONH for all modes of transport

[ WGK Germany ]:
3

[ HS Code ]:
2933990090

Customs

[ HS Code ]: 2933990090

[ Summary ]:
2933990090. heterocyclic compounds with nitrogen hetero-atom(s) only. VAT:17.0%. Tax rebate rate:13.0%. . MFN tariff:6.5%. General tariff:20.0%

Articles

Impairment of adenylyl cyclase-mediated glutamatergic synaptic plasticity in the periaqueductal grey in a rat model of neuropathic pain.

J. Physiol. 593 , 2955-73, (2015)

Long-lasting neuropathic pain has been attributed to elevated neuronal plasticity changes in spinal, peripheral and cortical levels. Here, we found that reduced neuronal plasticity in the ventrolatera...

Adaptation of NS cells growth and differentiation to high-throughput screening-compatible plates.

BMC Neurosci. 11 , 7, (2010)

There is an urgent need of neuronal cell models to be applied to high-throughput screening settings while recapitulating physiological and/or pathological events occurring in the Central Nervous Syste...

Characterization of Dahl salt-sensitive rats with genetic disruption of the A2B adenosine receptor gene: implications for A2B adenosine receptor signaling during hypertension.

Purinergic Signal. 11 , 519-31, (2015)

The A(2B) adenosine receptor (AR) has emerged as a unique member of the AR family with contrasting roles during acute and chronic disease states. We utilized zinc-finger nuclease technology to create ...