29925-17-5
29925-17-5 structure
- Name: RO 20-1724
- Chemical Name: 4-(3-Butoxy-4-methoxybenzyl)imidazolidin-2-one
- CAS Number: 29925-17-5
- Molecular Formula: C15H22N2O3
- Molecular Weight: 278.35
- Catalog: Signaling Pathways Metabolic Enzyme/Protease Phosphodiesterase (PDE)
- Create Date: 2018-07-25 13:09:06
- Modify Date: 2024-01-06 13:58:14
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Ro 20-1724 (Ro 20-174) is a potent inhibitor of cAMP-specific phosphodiesterase (PDE4/PDE IV) with a Ki of 1930 nM. Neuroprotective effect[1][2].
| Name | 4-(3-Butoxy-4-methoxybenzyl)imidazolidin-2-one |
|---|---|
| Synonyms |
MFCD00077397
4-[(3-butoxy-4-methoxyphenyl)methyl]-2-imidazolidinone |
| Description | Ro 20-1724 (Ro 20-174) is a potent inhibitor of cAMP-specific phosphodiesterase (PDE4/PDE IV) with a Ki of 1930 nM. Neuroprotective effect[1][2]. |
|---|---|
| Related Catalog | |
| Target |
PDE4:1930 nM (Ki) |
| In Vivo | Ro 20-1724 (125, 250 and 500 μg/kg; i.p.; 21 days following first i.c.v. streptozotocin administration; 200-250 g adult (3-5 months old) male albino Wistar rats) significantly attenuated streptozotocin induced cognitive deficit and oxidative stress[2]. |
| References |
| Density | 1.099 g/cm3 |
|---|---|
| Boiling Point | 483.8ºC at 760 mmHg |
| Molecular Formula | C15H22N2O3 |
| Molecular Weight | 278.35 |
| Flash Point | 246.4ºC |
| Exact Mass | 278.16300 |
| PSA | 59.59000 |
| LogP | 2.75560 |
| Vapour Pressure | 1.62E-09mmHg at 25°C |
| Index of Refraction | 1.521 |
| Storage condition | Store at RT |
| Water Solubility | ethanol: 7 mg/mL |
| Personal Protective Equipment | dust mask type N95 (US);Eyeshields;Gloves |
|---|---|
| Hazard Codes | Xi: Irritant; |
| Risk Phrases | R36/37/38 |
| Safety Phrases | S26-S36 |
| RIDADR | NONH for all modes of transport |
| WGK Germany | 3 |
| HS Code | 2933990090 |
| HS Code | 2933990090 |
|---|---|
| Summary | 2933990090. heterocyclic compounds with nitrogen hetero-atom(s) only. VAT:17.0%. Tax rebate rate:13.0%. . MFN tariff:6.5%. General tariff:20.0% |