RO-3306
RO-3306 structure
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Common Name | RO-3306 | ||
|---|---|---|---|---|
| CAS Number | 872573-93-8 | Molecular Weight | 351.445 | |
| Density | 1.4±0.1 g/cm3 | Boiling Point | 569.1±60.0 °C at 760 mmHg | |
| Molecular Formula | C18H13N3OS2 | Melting Point | N/A | |
| MSDS | USA | Flash Point | 298.0±32.9 °C | |
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CDK1 substitutes for mTOR kinase to activate mitotic cap-dependent protein translation.
Proc. Natl. Acad. Sci. U. S. A. 112 , 5875-82, (2015) Mitosis is commonly thought to be associated with reduced cap-dependent protein translation. Here we show an alternative control mechanism for maintaining cap-dependent translation during mitosis revealed by a viral oncoprotein, Merkel cell polyomavirus small... |
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JNK2 controls fragmentation of the Golgi complex and the G2/M transition through phosphorylation of GRASP65.
J. Cell Sci. 128 , 2249-60, (2015) In mammalian cells, the Golgi complex is composed of stacks that are connected by membranous tubules. During G2, the Golgi complex is disassembled into isolated stacks. This process is required for entry into mitosis, indicating that the correct inheritance o... |
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A Cholesterol-Dependent Endocytic Mechanism Generates Midbody Tubules During Cytokinesis.
Traffic 16 , 1174-92, (2015) Cytokinesis is the final stage of cell division and produces two independent daughter cells. Vesicles derived from internal membrane stores, such as the Golgi, lysosomes, and early and recycling endosomes accumulate at the intracellular bridge (ICB) during cy... |
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Histone Deacetylase 10 Regulates the Cell Cycle G2/M Phase Transition via a Novel Let-7-HMGA2-Cyclin A2 Pathway.
Mol. Cell. Biol. 35 , 3547-65, (2015) Histone deacetylase (HDAC) inhibition leads to cell cycle arrest in G1 and G2, suggesting HDACs as therapeutic targets for cancer and diseases linked to abnormal cell growth and proliferation. Many HDACs are transcriptional repressors. Some may alter cell cyc... |
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Functional high-throughput screening identifies the miR-15 microRNA family as cellular restriction factors for Salmonella infection.
Nat. Commun. 5 , 4718, (2014) Increasing evidence suggests an important role for miRNAs in the molecular interplay between bacterial pathogens and host cells. Here we perform a fluorescence microscopy-based screen using a library of miRNA mimics and demonstrate that miRNAs modulate Salmon... |