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NVP 2

Names

[ CAS No. ]:
1263373-43-8

[ Name ]:
NVP 2

[Synonym ]:
2H-Pyran-4-carbonitrile, 4-[[[5'-chloro-2'-[[trans-4-[[(1R)-2-methoxy-1-methylethyl]amino]cyclohexyl]amino][2,4'-bipyridin]-6-yl]amino]methyl]tetrahydro-
4-[({5'-Chloro-2'-[(trans-4-{[(2R)-1-methoxy-2-propanyl]amino}cyclohexyl)amino]-2,4'-bipyridin-6-yl}amino)methyl]tetrahydro-2H-pyran-4-carbonitrile
NVP-2

Biological Activity

[Description]:

NVP-2 is a CDK9 inhibitor with an IC50 of 0.5 nM.

[Related Catalog]:

Signaling Pathways >> Cell Cycle/DNA Damage >> CDK
Research Areas >> Cancer

[Target]

CDK9:0.5 nM (IC50)


[References]

[1]. Wang J, et al. SnapShot: Kinase Inhibitors I. Mol Cell. 2015 May 21;58(4):708.e1.


[Related Small Molecules]

Abemaciclib(LY2835219) | Ribociclib (LEE011) | Dinaciclib (SCH727965) | THZ1 2HCl | Roscovitine (CYC202) | THZ531 | RO-3306 | Flavopiridol | BAY-1143572 Racemate | CYC-065 | AZD5438 | BIO | Kenpaullone | SNS-032 (BMS-387032) | CDK9-IN-2

Chemical & Physical Properties

[ Density]:
1.2±0.1 g/cm3

[ Boiling Point ]:
704.5±60.0 °C at 760 mmHg

[ Molecular Formula ]:
C27H37ClN6O2

[ Molecular Weight ]:
513.075

[ Flash Point ]:
379.9±32.9 °C

[ Exact Mass ]:
512.266663

[ LogP ]:
3.28

[ Vapour Pressure ]:
0.0±2.2 mmHg at 25°C

[ Index of Refraction ]:
1.594

[ Storage condition ]:
2-8℃

Related Compounds