Galantamine hydrobromide

Modify Date: 2024-01-02 08:10:43

Galantamine hydrobromide structure	Common Name	Galantamine hydrobromide
	CAS Number	1953-04-4	Molecular Weight	368.266
	Density	N/A	Boiling Point	N/A
	Molecular Formula	C₁₇H₂₂BrNO₃	Melting Point	256 °C
	MSDS	Chinese USA	Flash Point	N/A
	Symbol	GHS06	Signal Word	Danger

Use of Galantamine hydrobromide

Galanthamine hydrobromide is a long-acting, centrally active acetylcholinesterase(AChE) inhibitor (IC50 = 410 nM) and allosteric potentiator at neuronal nicotinic ACh receptors. IC50 Value: 410 nM Target: AChEGalanthamine hydrobromide prevents β-amyloid-induced apoptosis in SH-SY5Y and bovine chromaffin cells. Long-term administration reduces amyloid precursor protein deposition and neurodegeneration in a mouse model of Alzheimer's disease.

Name	Galanthamine hydrobromide
Synonym	More Synonyms

Description	Galanthamine hydrobromide is a long-acting, centrally active acetylcholinesterase(AChE) inhibitor (IC50 = 410 nM) and allosteric potentiator at neuronal nicotinic ACh receptors. IC50 Value: 410 nM Target: AChEGalanthamine hydrobromide prevents β-amyloid-induced apoptosis in SH-SY5Y and bovine chromaffin cells. Long-term administration reduces amyloid precursor protein deposition and neurodegeneration in a mouse model of Alzheimer's disease.
Related Catalog	Signaling Pathways >> Neuronal Signaling >> AChE Research Areas >> Neurological Disease
References	[1]. Kita Y, Ago Y, Takano E, Fukada A, Takuma K, Matsuda T.Galantamine increases hippocampal insulin-like growth factor 2 expression via α7 nicotinic acetylcholine receptors in mice.Psychopharmacology (Berl). 2012 Aug 30. [2]. Berkov S, Viladomat F, Codina C, Suárez S, Ravelo A, Bastida J.GC-MS of amaryllidaceous galanthamine-type alkaloids.J Mass Spectrom. 2012 Aug;47(8):1065-73. [3]. Park CW, Son DD, Kim JY, Oh TO, Ha JM, Rhee YS, Park ES.Investigation of formulation factors affecting in vitro and in vivo characteristics of a galantamine transdermal system.Int J Pharm. 2012 Oct 15;436(1-2):32-40. Epub 2012 Jul 5. [4]. Park YS, Kim SH, Kim SY, Kim YH, Lee MH, Yang SC, Shaw LM, Kang JS.Quantification of Galantamine in Human Plasma by Validated Liquid Chromatography-Tandem Mass Spectrometry using Glimepride as an Internal Standard: Application to Bioavailability Studies in 32 Healthy Korean Subjects.J Chromatogr Sci. 2012 Jun 28. [5]. Arias et al Galantamine prevents apoptosis induced by b-amyloid and thapsigargin: involvement of nicotinic acetycholine receptors. Neuropharmacology (2004) 46 103.

Description

Related Catalog

Signaling Pathways >> Neuronal Signaling >> AChE

Research Areas >> Neurological Disease

References

[1]. Kita Y, Ago Y, Takano E, Fukada A, Takuma K, Matsuda T.Galantamine increases hippocampal insulin-like growth factor 2 expression via α7 nicotinic acetylcholine receptors in mice.Psychopharmacology (Berl). 2012 Aug 30.

[2]. Berkov S, Viladomat F, Codina C, Suárez S, Ravelo A, Bastida J.GC-MS of amaryllidaceous galanthamine-type alkaloids.J Mass Spectrom. 2012 Aug;47(8):1065-73.

[3]. Park CW, Son DD, Kim JY, Oh TO, Ha JM, Rhee YS, Park ES.Investigation of formulation factors affecting in vitro and in vivo characteristics of a galantamine transdermal system.Int J Pharm. 2012 Oct 15;436(1-2):32-40. Epub 2012 Jul 5.

[4]. Park YS, Kim SH, Kim SY, Kim YH, Lee MH, Yang SC, Shaw LM, Kang JS.Quantification of Galantamine in Human Plasma by Validated Liquid Chromatography-Tandem Mass Spectrometry using Glimepride as an Internal Standard: Application to Bioavailability Studies in 32 Healthy Korean Subjects.J Chromatogr Sci. 2012 Jun 28.

[5]. Arias et al Galantamine prevents apoptosis induced by b-amyloid and thapsigargin: involvement of nicotinic acetycholine receptors. Neuropharmacology (2004) 46 103.

Melting Point	256 °C
Molecular Formula	C₁₇H₂₂BrNO₃
Molecular Weight	368.266
Exact Mass	367.078308
PSA	41.93000
LogP	2.74630
Vapour Pressure	0mmHg at 25°C
Index of Refraction	-95 ° (C=1.4, H2O)
Storage condition	−20°C

Galantamine hydrobromide MSDS(Chinese)

Symbol	GHS06
Signal Word	Danger
Hazard Statements	H301
Precautionary Statements	P301 + P310
Personal Protective Equipment	Eyeshields;Faceshields;Gloves;type P2 (EN 143) respirator cartridges
Hazard Codes	T
Risk Phrases	R25:Toxic if swallowed.
Safety Phrases	45-36/37/39-22
RIDADR	UN 2811 6.1/PG 3
WGK Germany	3
RTECS	DF8075000

Precursor 8
CAS#:510-77-0 Galanthaminone CAS#:357-70-0 Galantamine CAS#:807362-55-6 (-)-galantamine... CAS#:122584-18-3 N-(p-Hydroxyphe...
CAS#:5392-10-9 2-Bromo-4,5-dim... CAS#:120-14-9 veratraldehyde CAS#:2973-59-3 2-Bromoisovanillin CAS#:179107-93-8 4-bromo-5-((4-h...
DownStream 3
CAS#:60755-80-8 O-Desmethyl gal... CAS#:41303-74-6 N-Desmethyl Gal... CAS#:357-70-0 Galantamine

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J. Chromatogr. A. 1374 , 122-33, (2014)

The present study investigated the practical use of modern ultra-high performance liquid chromatography (UHPLC) separation techniques for drug metabolite profiling, aiming to develop a widely applicab...

Galantamine-loaded PLGA nanoparticles, from nano-emulsion templating, as novel advanced drug delivery systems to treat neurodegenerative diseases.

Nanoscale 7 , 12076-84, (2015)

Polymeric nanoparticles could be promising drug delivery systems to treat neurodegenerative diseases. Among the various methods of nanoparticle preparation, nano-emulsion templating was used in the pr...

Acetylcholine excites neocortical pyramidal neurons via nicotinic receptors.

J. Neurophysiol. 113 , 2195-209, (2015)

The neuromodulator acetylcholine (ACh) shapes neocortical function during sensory perception, motor control, arousal, attention, learning, and memory. Here we investigate the mechanisms by which ACh a...

(4aS,6R,8aS)-3-Methoxy-11-methyl-5,6,9,10,11,12-hexahydro-4aH-[1]benzofuro[3a,3,2-ef][2]benzazepin-6-olhydrobromid

NIVALIN,HBR

MFCD00067672

(4aS,6R,8aS)-3-methoxy-11-methyl-5,6,9,10,11,12-hexahydro-4aH-[1]benzofuro[3a,3,2-ef][2]benzazepin-6-ol hydrobromide

(4aS,6R,8aS)-3-méthoxy-11-méthyl-5,6,9,10,11,12-hexahydro-4aH-[1]benzofuro[3a,3,2-ef][2]benzazépin-6-ol bromhydrate

Galanthamine hydrobromide (1:1)

GALANTHAMIDE HYDROBROMIDE

[3H]-Galantamine hydrobromide

UNII:5N4SA4KQX9

galanthamine bromhydrate (1:1)

Galantamine hydrobromide (JAN/USAN)

Galanthamine HBr

Galanthamine (hydrobromide)

Galantamine hydrobromide

(-)-Galanthaminium bromide

NIVALIN

6H-Benzofuro[3a,3,2-ef][2]benzazepin-6-ol, 4a,5,9,10,11,12-hexahydro-3-methoxy-11-methyl-, (4aS,6R,8aS)-, hydrobromide (1:1)

galanthaminhydrobromid(1:1)

GALANTHAMINE HYDROBROMIDUM

EINECS 217-780-5

GALANTAMINE HBR

6H-benzofuro[3a,3,2-ef][2]benzazepin-6-ol, 4a,5,9,10,11,12-hexahydro-3-methoxy-11-methyl-, (4aS,6R,8aS)-, hydrobromide

BioBioPha
China
Product Name: Galantamine hydrobromide
Price: ￥Inquiry/20mg
Purity: 98.0%
Stocking Period: 1 Day
Contact: Xueping-Zheng

Shanghai Jizhi Biochemical Technology Co., Ltd
China
Product Name: Galantamine hydrobromide
Price: ￥1688.0/500mg ￥658.0/100mg ￥3478.0/1g ￥298.0/20mg
Purity: 98.0%
Stocking Period: 2 Day
Contact: Liu jia

DC Chemicals Limited
China
Product Name: Galanthamine hydrobromide
Price: $Inquiry/20mg $Inquiry/100mg $300.0/1g
Purity: 98.0%
Stocking Period: 3 Day
Contact: Tony Cao

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Galantamine hydrobromide

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