Galanthaminone

Modify Date: 2024-01-02 19:01:36

Galanthaminone Structure
Galanthaminone structure
Common Name Galanthaminone
CAS Number 510-77-0 Molecular Weight 285.338
Density 1.3±0.1 g/cm3 Boiling Point 397.4±42.0 °C at 760 mmHg
Molecular Formula C17H19NO3 Melting Point 175-180ºC (dec.)
MSDS N/A Flash Point 194.1±27.9 °C

 Use of Galanthaminone


Galanthaminone (Narwedin) is a competitive and reversible cholinesterase (AChE) inhibitor; is used for the treatment of mild to moderate Alzheimer's disease and various other memory impairments.

 Names

Name N6-p-Methoxyphenyladenosin
Synonym More Synonyms

 Galanthaminone Biological Activity

Description Galanthaminone (Narwedin) is a competitive and reversible cholinesterase (AChE) inhibitor; is used for the treatment of mild to moderate Alzheimer's disease and various other memory impairments.
Related Catalog
Target

AChE

In Vitro Galanthaminone reduces the action of AChE and therefore tends to increase the concentration of acetylcholine in the brain. is also an allosteric ligand at nicotinic acetylcholine receptors. It has shown activity in modulating the nicotinic cholinergic receptors on cholinergic neurons to increase acetylcholine release.
In Vivo Absorption of Galanthaminone is rapid and complete and shows linear pharmacokinetics. It is well absorbed with absolute oral bioavailability between 80 and 100%. It has a half-life of seven hours. Peak effect of inhibiting acetylcholinesterase was achieved about one hour after a single oral dose of 8 mg in some healthy volunteers.
References

[1]. Greenblatt HM, et al. Structure of acetylcholinesterase complexed with (-)-galanthamine at 2.3 A resolution. FEBS Lett. 1999 Dec 17;463(3):321-6.

[2]. Heinrich M, et al. Galanthamine from snowdrop--the development of a modern drug against Alzheimer's disease from local Caucasian knowledge. J Ethnopharmacol. 2004 Jun;92(2-3):147-62.

 Chemical & Physical Properties

Density 1.3±0.1 g/cm3
Boiling Point 397.4±42.0 °C at 760 mmHg
Melting Point 175-180ºC (dec.)
Molecular Formula C17H19NO3
Molecular Weight 285.338
Flash Point 194.1±27.9 °C
Exact Mass 285.136505
PSA 38.77000
LogP 1.04
Vapour Pressure 0.0±0.9 mmHg at 25°C
Index of Refraction 1.626
Storage condition -20°C Freezer

 Safety Information

HS Code 2942000000

 Synthetic Route

 Customs

HS Code 2942000000

 Synonyms

6H-Benzofuro[3a,3,2-ef][2]benzazepin-6-one, 4a,5,9,10,11,12-hexahydro-3-methoxy-11-methyl-, (4aR,8aR)-
(4aR,8aR)-3-Methoxy-11-methyl-4a,5,9,10,11,12-hexahydro-6H-[1]benzofuro[3a,3,2-ef][2]benzazepin-6-one
Galanthaminone
(+)-narwedine
6-methoxy-10-methyl-galantham-1-en-3-one
Narwedine
(-)-Narwedine
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