DC Chemicals Limited
China
Product Name: (-)-Narwedine
Price: $400.0/100mg $700.0/250mg $1500.0/1g
Purity: 98.0%
Stocking Period: 3 Day
Contact: Tony Cao

Dayang Chem (Hangzhou) Co., Ltd.
China
Product Name: Galanthaminone
Price: $Inquiry/100g $Inquiry/1kg $Inquiry/100kg $Inquiry/1000kg
Purity: 98.0%
Stocking Period: Inquiry
Contact: Ms Wang

510-77-0

510-77-0 structure

510-77-0 structure

Name: Galanthaminone
Chemical Name: N6-p-Methoxyphenyladenosin
CAS Number: 510-77-0
Molecular Formula: C₁₇H₁₉NO₃
Molecular Weight: 285.338
Catalog: API Nervous system medication Cholinergic
Create Date: 2018-03-17 08:00:00
Modify Date: 2024-01-02 19:01:36
Galanthaminone (Narwedin) is a competitive and reversible cholinesterase (AChE) inhibitor; is used for the treatment of mild to moderate Alzheimer's disease and various other memory impairments.

Name	N6-p-Methoxyphenyladenosin
Synonyms	6H-Benzofuro[3a,3,2-ef][2]benzazepin-6-one, 4a,5,9,10,11,12-hexahydro-3-methoxy-11-methyl-, (4aR,8aR)- (4aR,8aR)-3-Methoxy-11-methyl-4a,5,9,10,11,12-hexahydro-6H-[1]benzofuro[3a,3,2-ef][2]benzazepin-6-one Galanthaminone (+)-narwedine 6-methoxy-10-methyl-galantham-1-en-3-one Narwedine (-)-Narwedine

Description	Galanthaminone (Narwedin) is a competitive and reversible cholinesterase (AChE) inhibitor; is used for the treatment of mild to moderate Alzheimer's disease and various other memory impairments.
Related Catalog	Signaling Pathways >> Neuronal Signaling >> AChE Research Areas >> Neurological Disease
Target	AChE
In Vitro	Galanthaminone reduces the action of AChE and therefore tends to increase the concentration of acetylcholine in the brain. is also an allosteric ligand at nicotinic acetylcholine receptors. It has shown activity in modulating the nicotinic cholinergic receptors on cholinergic neurons to increase acetylcholine release.
In Vivo	Absorption of Galanthaminone is rapid and complete and shows linear pharmacokinetics. It is well absorbed with absolute oral bioavailability between 80 and 100%. It has a half-life of seven hours. Peak effect of inhibiting acetylcholinesterase was achieved about one hour after a single oral dose of 8 mg in some healthy volunteers.
References	[1]. Greenblatt HM, et al. Structure of acetylcholinesterase complexed with (-)-galanthamine at 2.3 A resolution. FEBS Lett. 1999 Dec 17;463(3):321-6. [2]. Heinrich M, et al. Galanthamine from snowdrop--the development of a modern drug against Alzheimer's disease from local Caucasian knowledge. J Ethnopharmacol. 2004 Jun;92(2-3):147-62.

Density	1.3±0.1 g/cm3
Boiling Point	397.4±42.0 °C at 760 mmHg
Melting Point	175-180ºC (dec.)
Molecular Formula	C₁₇H₁₉NO₃
Molecular Weight	285.338
Flash Point	194.1±27.9 °C
Exact Mass	285.136505
PSA	38.77000
LogP	1.04
Vapour Pressure	0.0±0.9 mmHg at 25°C
Index of Refraction	1.626
Storage condition	-20°C Freezer

HS Code	2942000000

Precursor 10
357-70-0 510-77-0 296237-49-5 122584-14-9
252869-10-6 122584-18-3 5392-10-9 120-14-9
2973-59-3 179107-93-8
DownStream 4
357-70-0 510-77-0 1953-04-4 1668-85-5

HS Code	2942000000