1953-04-4

1953-04-4 structure

Name: Galantamine hydrobromide
Chemical Name: Galanthamine hydrobromide
CAS Number: 1953-04-4
Molecular Formula: C₁₇H₂₂BrNO₃
Molecular Weight: 368.266
Catalog: API Nervous system medication Cholinergic
Create Date: 2018-03-30 08:00:00
Modify Date: 2024-01-02 08:10:43
Galanthamine hydrobromide is a long-acting, centrally active acetylcholinesterase(AChE) inhibitor (IC50 = 410 nM) and allosteric potentiator at neuronal nicotinic ACh receptors. IC50 Value: 410 nM Target: AChEGalanthamine hydrobromide prevents β-amyloid-induced apoptosis in SH-SY5Y and bovine chromaffin cells. Long-term administration reduces amyloid precursor protein deposition and neurodegeneration in a mouse model of Alzheimer's disease.

Name	Galanthamine hydrobromide
Synonyms	(4aS,6R,8aS)-3-Methoxy-11-methyl-5,6,9,10,11,12-hexahydro-4aH-[1]benzofuro[3a,3,2-ef][2]benzazepin-6-olhydrobromid NIVALIN,HBR MFCD00067672 (4aS,6R,8aS)-3-methoxy-11-methyl-5,6,9,10,11,12-hexahydro-4aH-[1]benzofuro[3a,3,2-ef][2]benzazepin-6-ol hydrobromide (4aS,6R,8aS)-3-méthoxy-11-méthyl-5,6,9,10,11,12-hexahydro-4aH-[1]benzofuro[3a,3,2-ef][2]benzazépin-6-ol bromhydrate Galanthamine hydrobromide (1:1) GALANTHAMIDE HYDROBROMIDE [3H]-Galantamine hydrobromide UNII:5N4SA4KQX9 galanthamine bromhydrate (1:1) Galantamine hydrobromide (JAN/USAN) Galanthamine HBr Galanthamine (hydrobromide) Galantamine hydrobromide (-)-Galanthaminium bromide NIVALIN 6H-Benzofuro[3a,3,2-ef][2]benzazepin-6-ol, 4a,5,9,10,11,12-hexahydro-3-methoxy-11-methyl-, (4aS,6R,8aS)-, hydrobromide (1:1) galanthaminhydrobromid(1:1) GALANTHAMINE HYDROBROMIDUM EINECS 217-780-5 GALANTAMINE HBR 6H-benzofuro[3a,3,2-ef][2]benzazepin-6-ol, 4a,5,9,10,11,12-hexahydro-3-methoxy-11-methyl-, (4aS,6R,8aS)-, hydrobromide

Description	Galanthamine hydrobromide is a long-acting, centrally active acetylcholinesterase(AChE) inhibitor (IC50 = 410 nM) and allosteric potentiator at neuronal nicotinic ACh receptors. IC50 Value: 410 nM Target: AChEGalanthamine hydrobromide prevents β-amyloid-induced apoptosis in SH-SY5Y and bovine chromaffin cells. Long-term administration reduces amyloid precursor protein deposition and neurodegeneration in a mouse model of Alzheimer's disease.
Related Catalog	Signaling Pathways >> Neuronal Signaling >> AChE Research Areas >> Neurological Disease
References	[1]. Kita Y, Ago Y, Takano E, Fukada A, Takuma K, Matsuda T.Galantamine increases hippocampal insulin-like growth factor 2 expression via α7 nicotinic acetylcholine receptors in mice.Psychopharmacology (Berl). 2012 Aug 30. [2]. Berkov S, Viladomat F, Codina C, Suárez S, Ravelo A, Bastida J.GC-MS of amaryllidaceous galanthamine-type alkaloids.J Mass Spectrom. 2012 Aug;47(8):1065-73. [3]. Park CW, Son DD, Kim JY, Oh TO, Ha JM, Rhee YS, Park ES.Investigation of formulation factors affecting in vitro and in vivo characteristics of a galantamine transdermal system.Int J Pharm. 2012 Oct 15;436(1-2):32-40. Epub 2012 Jul 5. [4]. Park YS, Kim SH, Kim SY, Kim YH, Lee MH, Yang SC, Shaw LM, Kang JS.Quantification of Galantamine in Human Plasma by Validated Liquid Chromatography-Tandem Mass Spectrometry using Glimepride as an Internal Standard: Application to Bioavailability Studies in 32 Healthy Korean Subjects.J Chromatogr Sci. 2012 Jun 28. [5]. Arias et al Galantamine prevents apoptosis induced by b-amyloid and thapsigargin: involvement of nicotinic acetycholine receptors. Neuropharmacology (2004) 46 103.

Melting Point	256 °C
Molecular Formula	C₁₇H₂₂BrNO₃
Molecular Weight	368.266
Exact Mass	367.078308
PSA	41.93000
LogP	2.74630
Vapour Pressure	0mmHg at 25°C
Index of Refraction	-95 ° (C=1.4, H2O)
Storage condition	−20°C

Symbol	GHS06
Signal Word	Danger
Hazard Statements	H301
Precautionary Statements	P301 + P310
Personal Protective Equipment	Eyeshields;Faceshields;Gloves;type P2 (EN 143) respirator cartridges
Hazard Codes	T
Risk Phrases	R25:Toxic if swallowed.
Safety Phrases	45-36/37/39-22
RIDADR	UN 2811 6.1/PG 3
WGK Germany	3
RTECS	DF8075000

Precursor 8
510-77-0 357-70-0 807362-55-6 122584-18-3
5392-10-9 120-14-9 2973-59-3 179107-93-8
DownStream 3
60755-80-8 41303-74-6 357-70-0

1953-04-4	357-70-0
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