Galantamine hydrobromide
Galantamine hydrobromide structure
|
Common Name | Galantamine hydrobromide | ||
|---|---|---|---|---|
| CAS Number | 1953-04-4 | Molecular Weight | 368.266 | |
| Density | N/A | Boiling Point | N/A | |
| Molecular Formula | C17H22BrNO3 | Melting Point | 256 °C | |
| MSDS | Chinese USA | Flash Point | N/A | |
| Symbol |
GHS06 |
Signal Word | Danger | |
|
Systematic evaluation of commercially available ultra-high performance liquid chromatography columns for drug metabolite profiling: optimization of chromatographic peak capacity.
J. Chromatogr. A. 1374 , 122-33, (2014) The present study investigated the practical use of modern ultra-high performance liquid chromatography (UHPLC) separation techniques for drug metabolite profiling, aiming to develop a widely applicable, high-throughput, easy-to-use chromatographic method, wi... |
|
|
Galantamine-loaded PLGA nanoparticles, from nano-emulsion templating, as novel advanced drug delivery systems to treat neurodegenerative diseases.
Nanoscale 7 , 12076-84, (2015) Polymeric nanoparticles could be promising drug delivery systems to treat neurodegenerative diseases. Among the various methods of nanoparticle preparation, nano-emulsion templating was used in the present study to prepare galantamine-loaded nano-emulsions by... |
|
|
Acetylcholine excites neocortical pyramidal neurons via nicotinic receptors.
J. Neurophysiol. 113 , 2195-209, (2015) The neuromodulator acetylcholine (ACh) shapes neocortical function during sensory perception, motor control, arousal, attention, learning, and memory. Here we investigate the mechanisms by which ACh affects neocortical pyramidal neurons in adult mice. Stimula... |
|
|
Nicotinic receptor-dependent and -independent effects of galantamine, an acetylcholinesterase inhibitor, on the non-neuronal acetylcholine system in C2C12 cells.
Int. Immunopharmacol. 29 , 31-5, (2015) We previously reported that satellite cells possess the ability to produce angiogenic factors, including fibroblast growth factor (FGF)-2 and vascular endothelial growth factor (VEGF) in vivo. However, whether C2C12 cells possess a non-neuronal cholinergic sy... |
|
|
Free energy, precision and learning: the role of cholinergic neuromodulation.
J. Neurosci. 33(19) , 8227-36, (2013) Acetylcholine (ACh) is a neuromodulatory transmitter implicated in perception and learning under uncertainty. This study combined computational simulations and pharmaco-electroencephalography in humans, to test a formulation of perceptual inference based upon... |
|
|
Layer-specific interference with cholinergic signaling in the prefrontal cortex by smoking concentrations of nicotine.
J. Neurosci. 33(11) , 4843-53, (2013) Adolescence is a period in which the developing prefrontal cortex (PFC) is sensitive to maladaptive changes when exposed to nicotine. Nicotine affects PFC function and repeated exposure to nicotine during adolescence impairs attention performance and impulse ... |
|
|
Flow-through enzyme immobilized amperometric detector for the rapid screening of acetylcholinesterase inhibitors by flow injection analysis.
J. Pharm. Biomed. Anal. 102 , 267-75, (2015) A commercially available thin-layer flow-through amperometric detector, with the sensing block customized in an original design, was applied to the screening of drug compounds known as acetylcholinesterase (AChE) inhibitors. AChE from electric eel was covalen... |
|
|
Hyperglycemia induces memory impairment linked to increased acetylcholinesterase activity in zebrafish (Danio rerio).
Behav. Brain Res. 274 , 319-25, (2014) Diabetes mellitus, which causes hyperglycemia, affects the central nervous system and can impairs cognitive functions, such as memory. The aim of this study was to investigate the effects of hyperglycemia on memory as well as on the activity of acethylcholine... |
|
|
[Effectiveness and limitation of newly approved drugs for Alzheimer's disease].
Seishin Shinkeigaku Zasshi 115(1) , 22-31, (2013) Galantamine, rivastigmine, and memantine, for the treatment of Alzheimer-type dementia, became covered by national health insurance last year in Japan. Galantamine and rivastigmine are choline esterase inhibitors, and memantine is a glutamate NMDA receptor an... |
|
|
Acetylcholinesterase inhibition promotes retinal vasoprotection and increases ocular blood flow in experimental glaucoma.
Invest. Ophthalmol. Vis. Sci. 54(5) , 3171-83, (2013) A clear correlation between vascular deficits and retinal ganglion cell (RGC) loss in glaucoma has not yet been established. The question arose as to whether there is loss of inner retinal vessels following intraocular pressure (IOP) increase and, if so, whet... |