ML 418

Modify Date: 2024-02-05 09:21:29

ML 418 Structure
ML 418 structure
Common Name ML 418
CAS Number 1928763-08-9 Molecular Weight 377.87
Density N/A Boiling Point N/A
Molecular Formula C19H24ClN3O3 Melting Point N/A
MSDS N/A Flash Point N/A

 Use of ML 418


ML418 is the first potent, selective and CNS penetrating blocker of Kir7.1 potassium channel (IC50, 310 nM), which also potently inhibits Kir6.2/SUR1, and exhibits superior selectivity over other Kir channels[1].

 Names

Name ML418
Synonym More Synonyms

 ML 418 Biological Activity

Description ML418 is the first potent, selective and CNS penetrating blocker of Kir7.1 potassium channel (IC50, 310 nM), which also potently inhibits Kir6.2/SUR1, and exhibits superior selectivity over other Kir channels[1].
Related Catalog
References

[1]. ML418, et al. ML418: The First Selective, Sub-Micromolar Pore Blocker of Kir7.1 Potassium Channels. ACS Chem Neurosci. 2016 Jul 20;7(7):1013-23.

 Chemical & Physical Properties

Molecular Formula C19H24ClN3O3
Molecular Weight 377.87
Storage condition -20°C

 Synonyms

MFCD32201056