1646499-97-9

1646499-97-9 structure

Name: ML 382
Chemical Name: 2-[(Cyclopropylsulfonyl)amino]-N-(2-ethoxyphenyl)benzamide
CAS Number: 1646499-97-9
Molecular Formula: C₁₈H₂₀N₂O₄S
Molecular Weight: 360.427
Catalog: Research Areas Neurological Disease
Create Date: 2020-01-20 10:12:56
Modify Date: 2024-01-17 22:06:04
ML382 is a potent, selective, positive allosteric modulator of Mas-related G protein-coupled receptor X1 (MrgprX1) with EC50 of 190 nM in cell based Ca2+ imaging assay; displays >100-fold selectivity versus MrgX2; enhances the ability of BAM8-22 to inhibit high-voltage-activated Ca2+ channels and attenuates spinal nociceptive transmission; effectively attenuated evoked, persistent, and spontaneous pain without causing obvious side effects; attenuates both evoked pain hypersensitivity and spontaneous pain in MrgprX1 mice; an invaluable research tool to study the role of MrgprX1 in chronic pain.

Name	2-[(Cyclopropylsulfonyl)amino]-N-(2-ethoxyphenyl)benzamide
Synonyms	MFCD30182354 Benzamide, 2-[(cyclopropylsulfonyl)amino]-N-(2-ethoxyphenyl)- 2-[(Cyclopropylsulfonyl)amino]-N-(2-ethoxyphenyl)benzamide

Description	ML382 is a potent, selective, positive allosteric modulator of Mas-related G protein-coupled receptor X1 (MrgprX1) with EC50 of 190 nM in cell based Ca2+ imaging assay; displays >100-fold selectivity versus MrgX2; enhances the ability of BAM8-22 to inhibit high-voltage-activated Ca2+ channels and attenuates spinal nociceptive transmission; effectively attenuated evoked, persistent, and spontaneous pain without causing obvious side effects; attenuates both evoked pain hypersensitivity and spontaneous pain in MrgprX1 mice; an invaluable research tool to study the role of MrgprX1 in chronic pain.
References	References 1. Wen W, et al. ChemMedChem. 2015 Jan;10(1):57-61. 2. Li Z, et al. Proc Natl Acad Sci U S A. 2017 Mar 7;114(10):E1996-E2005. View Related Products by Target Other Targets