ML 792
Modify Date: 2024-01-16 23:03:50
ML 792 structure
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Common Name | ML 792 | ||
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| CAS Number | 1644342-14-2 | Molecular Weight | 551.414 | |
| Density | 1.7±0.1 g/cm3 | Boiling Point | 815.1±75.0 °C at 760 mmHg | |
| Molecular Formula | C21H23BrN6O5S | Melting Point | N/A | |
| MSDS | N/A | Flash Point | 446.7±37.1 °C | |
Use of ML 792ML 792 is a potent, seletive SUMO-activating enzyme (SAE) inhibitor with IC50 of 3 nM and 11 nM for SAE/SUMO1 and SAE/SUMO2, respectively; shows no significant inhibition for closely related E1 enzymes NAE (IC50=32 uM) and ubiquitin-activating enzyme (UAE) (IC50 >100 uM), as well as a panel of 366 ATP-using enzymes; dose-dependently decreases global SUMOylation in HCT116 cells (EC50=19 nM), demonstrates potent antiproliferative effect in HCT116 cells and MDA-MB-231 cells with EC50 of 0.04 and 0.11 uM, respectively. |
| Name | {(1R,2S,4R)-4-[(5-{[1-(3-Bromobenzyl)-1H-pyrazol-3-yl]carbonyl}-4-pyrimidinyl)amino]-2-hydroxycyclopentyl}methyl sulfamate |
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| Synonym | More Synonyms |
| Description | ML 792 is a potent, seletive SUMO-activating enzyme (SAE) inhibitor with IC50 of 3 nM and 11 nM for SAE/SUMO1 and SAE/SUMO2, respectively; shows no significant inhibition for closely related E1 enzymes NAE (IC50=32 uM) and ubiquitin-activating enzyme (UAE) (IC50 >100 uM), as well as a panel of 366 ATP-using enzymes; dose-dependently decreases global SUMOylation in HCT116 cells (EC50=19 nM), demonstrates potent antiproliferative effect in HCT116 cells and MDA-MB-231 cells with EC50 of 0.04 and 0.11 uM, respectively. |
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| References | References 1. He X, et al. Nat Chem Biol. 2017 Sep 11. doi: 10.1038/nchembio.2463. View Related Products by Target Ubiquitin-activating Enzyme (E1) |
| Density | 1.7±0.1 g/cm3 |
|---|---|
| Boiling Point | 815.1±75.0 °C at 760 mmHg |
| Molecular Formula | C21H23BrN6O5S |
| Molecular Weight | 551.414 |
| Flash Point | 446.7±37.1 °C |
| Exact Mass | 550.063416 |
| LogP | 1.71 |
| Vapour Pressure | 0.0±3.1 mmHg at 25°C |
| Index of Refraction | 1.740 |
| Sulfamic acid, [(1R,2S,4R)-4-[[5-[[1-[(3-bromophenyl)methyl]-1H-pyrazol-3-yl]carbonyl]-4-pyrimidinyl]amino]-2-hydroxycyclopentyl]methyl ester |
| {(1R,2S,4R)-4-[(5-{[1-(3-Bromobenzyl)-1H-pyrazol-3-yl]carbonyl}-4-pyrimidinyl)amino]-2-hydroxycyclopentyl}methyl sulfamate |