ML-224

Modify Date: 2024-01-01 23:16:29

ML-224 structure	Common Name	ML-224
	CAS Number	1338824-21-7	Molecular Weight	525.595
	Density	1.3±0.1 g/cm3	Boiling Point	752.3±60.0 °C at 760 mmHg
	Molecular Formula	C₃₁H₃₁N₃O₅	Melting Point	N/A
	MSDS	N/A	Flash Point	408.8±32.9 °C

Use of ML-224

ML224(NCGC00242364; ANTAG3) is a selective TSHR inverse agonist; inhibits TSH-stimulated cAMP production with an IC50 = 2.3 μM.IC50 value: 2.3 uM [1]Target: TSHR agonistin vitro: ANTAG3 was selective for TSHR inhibition; half-maximal inhibitory doses were 2.1 μM for TSHR and greater than 30 μM for LH and FSH receptors [2]. in vivo: In mice treated with TRH, ANTAG3 lowered serum free T4 by 44% and lowered mRNAs for sodium-iodide cotransporter and thyroperoxidase by 75% and 83%, respectively. In mice given M22, ANTAG3 lowered serum free T4 by 38% and lowered mRNAs for sodium-iodide cotransporter and thyroperoxidase by 73% and 40%, respectively [2].

Name	N-[4-({5-[3-(2-Furylmethyl)-4-oxo-1,2,3,4-tetrahydro-2-quinazolinyl]-2-methoxybenzyl}oxy)-3,5-dimethylphenyl]acetamide
Synonym	More Synonyms

Description	ML224(NCGC00242364; ANTAG3) is a selective TSHR inverse agonist; inhibits TSH-stimulated cAMP production with an IC50 = 2.3 μM.IC50 value: 2.3 uM [1]Target: TSHR agonistin vitro: ANTAG3 was selective for TSHR inhibition; half-maximal inhibitory doses were 2.1 μM for TSHR and greater than 30 μM for LH and FSH receptors [2]. in vivo: In mice treated with TRH, ANTAG3 lowered serum free T4 by 44% and lowered mRNAs for sodium-iodide cotransporter and thyroperoxidase by 75% and 83%, respectively. In mice given M22, ANTAG3 lowered serum free T4 by 38% and lowered mRNAs for sodium-iodide cotransporter and thyroperoxidase by 73% and 40%, respectively [2].
Related Catalog	Signaling Pathways >> GPCR/G Protein >> TSH Receptor Research Areas >> Endocrinology
References	[1]. Huang W, et al. Identification of Thyroid Stimulating Hormone Receptor Inverse Agonists. Probe Reports from the NIH Molecular Libraries Program [2]. Neumann S, et al. A selective TSH receptor antagonist inhibits stimulation of thyroid function in female mice. Endocrinology. 2014 Jan;155(1):310-4.

Description

Related Catalog

Signaling Pathways >> GPCR/G Protein >> TSH Receptor

Research Areas >> Endocrinology

References

[1]. Huang W, et al. Identification of Thyroid Stimulating Hormone Receptor Inverse Agonists. Probe Reports from the NIH Molecular Libraries Program

[2]. Neumann S, et al. A selective TSH receptor antagonist inhibits stimulation of thyroid function in female mice. Endocrinology. 2014 Jan;155(1):310-4.

Density	1.3±0.1 g/cm3
Boiling Point	752.3±60.0 °C at 760 mmHg
Molecular Formula	C₃₁H₃₁N₃O₅
Molecular Weight	525.595
Flash Point	408.8±32.9 °C
Exact Mass	525.226379
LogP	2.92
Vapour Pressure	0.0±2.5 mmHg at 25°C
Index of Refraction	1.626
Storage condition	2-8℃

N-[4-({5-[3-(2-Furylmethyl)-4-oxo-1,2,3,4-tetrahydro-2-quinazolinyl]-2-methoxybenzyl}oxy)-3,5-dimethylphenyl]acetamide

Acetamide, N-[4-[[5-[3-(2-furanylmethyl)-1,2,3,4-tetrahydro-4-oxo-2-quinazolinyl]-2-methoxyphenyl]methoxy]-3,5-dimethylphenyl]-

ML-224

ML224

DC Chemicals Limited
China
Product Name: ML-224
Price: $850.0/100mg $1500.0/250mg $2900.0/1g
Purity: 98.0%
Stocking Period: 3 Day
Contact: Tony Cao

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Price: $486/10mM*1mLinDMSO

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ML-224

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