1440251-53-5

1440251-53-5 structure

Name: ML 315
Chemical Name: ML 315 hydrochloride
CAS Number: 1440251-53-5
Molecular Formula: C₁₈H₁₃Cl₂N₃O₂
Molecular Weight: 374.22
Catalog: Signaling Pathways Cell Cycle/DNA Damage CDK
Create Date: 2022-03-28 12:28:07
Modify Date: 2025-08-25 16:15:35
ML 315 is a selective dual inhibitor of CDK and DYRK with IC50s of 68 nM and 282 nM, respectively. ML 315 is used in cancer and neurological disease research[1].

Name	ML 315 hydrochloride
Synonyms	MFCD30833328 5-(1,3-Benzodioxol-5-yl)-N-(3,5-dichlorobenzyl)-4-pyrimidinamine 4-Pyrimidinamine, 5-(1,3-benzodioxol-5-yl)-N-[(3,5-dichlorophenyl)methyl]- ML315 5-(1,3-Benzodioxol-5-yl)-N-[(3,5-dichlorophenyl)methyl]-4-pyrimidinamine hydrochloride

Description	ML 315 is a selective dual inhibitor of CDK and DYRK with IC50s of 68 nM and 282 nM, respectively. ML 315 is used in cancer and neurological disease research[1].
Related Catalog	Research Areas >> Cancer Signaling Pathways >> Protein Tyrosine Kinase/RTK >> DYRK Signaling Pathways >> Cell Cycle/DNA Damage >> CDK Research Areas >> Neurological Disease
References	[1]. Coombs TC, et al. Small-molecule pyrimidine inhibitors of the cdc2-like (Clk) and dual specificity tyrosine phosphorylation-regulated (Dyrk) kinases: development of chemical probe ML315. Bioorg Med Chem Lett. 2013 Jun 15;23(12):3654-61.