ML-109

Modify Date: 2024-01-10 12:13:50

ML-109 structure	Common Name	ML-109
	CAS Number	1186649-91-1	Molecular Weight	523.58
	Density	N/A	Boiling Point	N/A
	Molecular Formula	C₃₁H₂₉N₃O₅	Melting Point	N/A
	MSDS	N/A	Flash Point	N/A

Use of ML-109

ML-109 is a potent and full thyroid stimulating hormone receptor (TSHR) agonist, with an EC50 of 40 nM.

Name	ML-109

Description	ML-109 is a potent and full thyroid stimulating hormone receptor (TSHR) agonist, with an EC50 of 40 nM.
Related Catalog	Signaling Pathways >> GPCR/G Protein >> TSH Receptor Research Areas >> Metabolic Disease
Target	EC50: 40 nM (TSHR)[1].
In Vitro	ML-109 (Compound 2) is a full agonist at TSHR with an EC50 of 40 nM and, like compound 1, it has no activity at FSHR or LHCGR. ML-109 contains an aminal, a functional group that is subject to hydrolysis and/or other degradation mechanisms. ML-109 is surprisingly stable at neutral and basic conditions (t1/2 of ~16 h) but is found to degrade at low pH (t1/2 of ~3 h)[1].
References	[1]. Neumann S, et al. Small-molecule agonists for the thyrotropin receptor stimulate thyroid function in human thyrocytes and mice. Proc Natl Acad Sci U S A. 2009 Jul 28;106(30):12471-6.

Molecular Formula	C₃₁H₂₉N₃O₅
Molecular Weight	523.58
Storage condition	2-8℃

DC Chemicals Limited
China
Product Name: ML-109
Price: $600.0/100mg $1100.0/250mg $2200.0/1g
Purity: 98.0%
Stocking Period: 3 Day
Contact: Tony Cao

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Price: ￥5500/5 mg

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