ML 281
Modify Date: 2025-08-27 11:28:27
ML 281 structure
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Common Name | ML 281 | ||
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| CAS Number | 1404437-62-2 | Molecular Weight | 389.47000 | |
| Density | N/A | Boiling Point | N/A | |
| Molecular Formula | C22H19N3O2S | Melting Point | N/A | |
| MSDS | N/A | Flash Point | N/A | |
Use of ML 281ML281 is a potent and selective STK33 inhibitor with IC50 of 14 nM. ML281 showed a 550-fold selectivity over AurB and greater than 700-fold selectivity over PKA.target: STK33IC50: 14 nM [1]ML281 showed low nanomolar inhibition of purified recombinant STK33 and a distinct selectivity profile as compared to other STK33 inhibitors. Even at the highest concentration tested (10 μM), ML281 had no effect on the viability of KRAS-dependent cancer cells. [2] |
| Name | N-(4-isopropyl-2-(3-oxo-3,4-dihydroquinoxalin-2-yl)phenyl)thiophene-2-carboxamide |
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| Synonym | More Synonyms |
| Description | ML281 is a potent and selective STK33 inhibitor with IC50 of 14 nM. ML281 showed a 550-fold selectivity over AurB and greater than 700-fold selectivity over PKA.target: STK33IC50: 14 nM [1]ML281 showed low nanomolar inhibition of purified recombinant STK33 and a distinct selectivity profile as compared to other STK33 inhibitors. Even at the highest concentration tested (10 μM), ML281 had no effect on the viability of KRAS-dependent cancer cells. [2] |
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| Related Catalog | |
| References |
| Molecular Formula | C22H19N3O2S |
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| Molecular Weight | 389.47000 |
| Exact Mass | 389.12000 |
| PSA | 103.09000 |
| LogP | 5.10030 |
| Storage condition | 2-8℃ |
| ML281 |