ML 281

Modify Date: 2024-01-08 12:28:01

ML 281 structure	Common Name	ML 281
	CAS Number	1404437-62-2	Molecular Weight	389.47000
	Density	N/A	Boiling Point	N/A
	Molecular Formula	C₂₂H₁₉N₃O₂S	Melting Point	N/A
	MSDS	N/A	Flash Point	N/A

Use of ML 281

ML281 is a potent and selective STK33 inhibitor with IC50 of 14 nM. ML281 showed a 550-fold selectivity over AurB and greater than 700-fold selectivity over PKA.target: STK33IC50: 14 nM [1]ML281 showed low nanomolar inhibition of purified recombinant STK33 and a distinct selectivity profile as compared to other STK33 inhibitors. Even at the highest concentration tested (10 μM), ML281 had no effect on the viability of KRAS-dependent cancer cells. [2]

Name	N-(4-isopropyl-2-(3-oxo-3,4-dihydroquinoxalin-2-yl)phenyl)thiophene-2-carboxamide
Synonym	More Synonyms

Description	ML281 is a potent and selective STK33 inhibitor with IC50 of 14 nM. ML281 showed a 550-fold selectivity over AurB and greater than 700-fold selectivity over PKA.target: STK33IC50: 14 nM [1]ML281 showed low nanomolar inhibition of purified recombinant STK33 and a distinct selectivity profile as compared to other STK33 inhibitors. Even at the highest concentration tested (10 μM), ML281 had no effect on the viability of KRAS-dependent cancer cells. [2]
Related Catalog	Signaling Pathways >> Others >> Others Research Areas >> Cancer
References	[1]. We?wer M et al. A Potent and Selective Quinoxalinone-Based STK33 Inhibitor Does Not Show Synthetic Lethality in KRAS-Dependent Cells. ACS Med Chem Lett, 2012 Dec 13, 3(12):1034-1038. [2]. Spoonamore J et al. Screen for Inhibitors of STK33 Kinase Activity. National Center for Biotechnology Information (US); 2010-2011 Dec 16.

Description

Related Catalog

Signaling Pathways >> Others >> Others

Research Areas >> Cancer

References

[1]. We?wer M et al. A Potent and Selective Quinoxalinone-Based STK33 Inhibitor Does Not Show Synthetic Lethality in KRAS-Dependent Cells. ACS Med Chem Lett, 2012 Dec 13, 3(12):1034-1038.

[2]. Spoonamore J et al. Screen for Inhibitors of STK33 Kinase Activity. National Center for Biotechnology Information (US); 2010-2011 Dec 16.

Molecular Formula	C₂₂H₁₉N₃O₂S
Molecular Weight	389.47000
Exact Mass	389.12000
PSA	103.09000
LogP	5.10030
Storage condition	2-8℃

ML281

DC Chemicals Limited
China
Product Name: ML281
Price: $550.0/100mg $1000.0/250mg $1900.0/1g
Purity: 98.0%
Stocking Period: 3 Day
Contact: Tony Cao

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Price: $119/10mM*1mLinDMSO

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ML 281

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