ML 10302 hydrochloride

Modify Date: 2024-01-09 20:24:24

ML 10302 hydrochloride Structure
ML 10302 hydrochloride structure
Common Name ML 10302 hydrochloride
CAS Number 186826-17-5 Molecular Weight 349.25300
Density N/A Boiling Point N/A
Molecular Formula C15H22Cl2N2O3 Melting Point N/A
MSDS N/A Flash Point N/A

 Use of ML 10302 hydrochloride


ML 10302 hydrochloride is a potent and selective 5-HT4 receptor agonist, with an EC50 of 4 nM。ML 10302 hydrochloride displays more than 680-fold selectivity over 5-HT3 receptor in binding assay[1][2].

 Names

Name 2-piperidin-1-ylethyl 4-amino-5-chloro-2-methoxybenzoate,hydrochloride

 ML 10302 hydrochloride Biological Activity

Description ML 10302 hydrochloride is a potent and selective 5-HT4 receptor agonist, with an EC50 of 4 nM。ML 10302 hydrochloride displays more than 680-fold selectivity over 5-HT3 receptor in binding assay[1][2].
Related Catalog
Target

5-HT4 Receptor:4 nM (EC50)

In Vitro ML 10302 hydrochloride shows Kis of 1.07 nM and 782 nM for 5-HT4 receptor and 5-HT3 receptor, respectively, in binding assay[1].
References

[1]. Langlois, M., et al. Design of a potent 5-HT4 receptor agonist with nanomolar affinity. Bioorganic & Medicinal Chemistry Letters. 1994. 4(12), 1433–1436.

[2]. D Yang, et al. New esters of 4-amino-5-chloro-2-methoxybenzoic acid as potent agonists and antagonists for 5-HT4 receptors. J Med Chem. 1997 Feb 14;40(4):608-21.

 Chemical & Physical Properties

Molecular Formula C15H22Cl2N2O3
Molecular Weight 349.25300
Exact Mass 348.10100
PSA 64.79000
LogP 3.89460
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