ML-9 Free Base

Modify Date: 2025-08-26 16:33:20

ML-9 Free Base Structure
ML-9 Free Base structure
 Common Name ML-9 Free Base
CAS Number 110448-31-2 Molecular Weight 324.82600
Density N/A Boiling Point N/A
Molecular Formula C15H17ClN2O2S Melting Point N/A
MSDS N/A Flash Point N/A

 Use of ML-9 Free Base


ML-9 (Free Base) is a selective and potent inhibitor of Akt kinase, inhibits myosin light-chain kinase (MLCK) and stromal interaction molecule 1 (STIM1) activity[3]. ML-9 (Free Base) inhibits inhibits MLCK, PKA and PKC activity with Ki values of 4, 32 and 54 μM, respectively[1]. ML-9 (Free Base) induces autophagy by stimulating autophagosome formation and inhibiting their degradation[3].

 Names

Name 1-(5-chloronaphthalen-1-yl)sulfonyl-1,4-diazepane
Synonym More Synonyms

 ML-9 Free Base Biological Activity

Description ML-9 (Free Base) is a selective and potent inhibitor of Akt kinase, inhibits myosin light-chain kinase (MLCK) and stromal interaction molecule 1 (STIM1) activity[3]. ML-9 (Free Base) inhibits inhibits MLCK, PKA and PKC activity with Ki values of 4, 32 and 54 μM, respectively[1]. ML-9 (Free Base) induces autophagy by stimulating autophagosome formation and inhibiting their degradation[3].
Related Catalog
In Vitro ML9 (Free Base) (0-100 μM; 0-24 hours) has no reduction in cardiomyocyte viability, 50-100 μM significantly induces cell death[2]. ML9 (Free Base) (50 μM; 1-4 hours) significantly increases cleaved caspase-3 levels, decreased STIM1 protein levels by about 42%[2]. Cell Viability Assay[1] Cell Line: Neonatal rat ventricular myocytes (NRVM) cells Concentration: 0, 10, 50 and 100 μM Incubation Time: 0, 1, 4, 8 and 24 hours Result: Decreased cell viability at 50–100 μM concentration. Apoptosis Analysis[1] Cell Line: Neonatal rat ventricular myocytes (NRVM) cells Concentration: 50 μM Incubation Time: 0, 1, 4, 8 hours Result: Induced cardiomyocyte death through necrosis and apoptosis.
References

[1]. Ito S, et al. ML-9, a myosin light chain kinase inhibitor, reduces intracellular Ca2+ concentration in guinea pig trachealis.Eur J Pharmacol. 2004 Feb 23;486(3):325-33.

[2]. Shaikh S, et al. The STIM1 inhibitor ML9 disrupts basal autophagy in cardiomyocytes by decreasing lysosome content.Toxicol In Vitro. 2018 Apr;48:121-127.

[3]. Kondratskyi A1, et al.Identification of ML-9 as a lysosomotropic agent targeting autophagy and cell death.Cell Death Dis. 2014 Apr 24;5:e1193.

 Chemical & Physical Properties

Molecular Formula C15H17ClN2O2S
Molecular Weight 324.82600
Exact Mass 324.07000
PSA 57.79000
LogP 3.82470
InChIKey OZSMSRIUUDGTEP-UHFFFAOYSA-N
SMILES O=S(=O)(c1cccc2c(Cl)cccc12)N1CCCNCC1

 Safety Information

Hazard Codes Xi

 Synonyms

Lopac-C-1172
1H-1,4-Diazepine,1-[(5-chloro-1-naphthalenyl)sulfonyl]hexahydro
Tocris-0431
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