FNDR-20123 free base
Modify Date: 2024-04-11 19:41:06
FNDR-20123 free base structure
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Common Name | FNDR-20123 free base | ||
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| CAS Number | 1267502-34-0 | Molecular Weight | 377.44 | |
| Density | N/A | Boiling Point | N/A | |
| Molecular Formula | C21H23N5O2 | Melting Point | N/A | |
| MSDS | N/A | Flash Point | N/A | |
Use of FNDR-20123 free baseFNDR-20123 free base is an orally active, safe and a first-in-class anti-malarial HDAC inhibitor with IC50s of 31 nM and 3 nM for Plasmodium and human HDAC, respectively. FNDR-20123 free base exerts anti-malarial activity against Plasmodium falciparum asexual stage (IC50=41 nM) and sexual blood stage (IC50=190 nM for male gametocytes). FNDR-20123 free base inhibits HDAC1, HDAC2, HDAC3, HDAC6, and HDAC8 (IC50=25, 29, 2, 11, and 282 nM, respectively) and inhibits Class III HDAC isoforms at nanomolar concentrations. |
| Name | FNDR-20123 free base |
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| Description | FNDR-20123 free base is an orally active, safe and a first-in-class anti-malarial HDAC inhibitor with IC50s of 31 nM and 3 nM for Plasmodium and human HDAC, respectively. FNDR-20123 free base exerts anti-malarial activity against Plasmodium falciparum asexual stage (IC50=41 nM) and sexual blood stage (IC50=190 nM for male gametocytes). FNDR-20123 free base inhibits HDAC1, HDAC2, HDAC3, HDAC6, and HDAC8 (IC50=25, 29, 2, 11, and 282 nM, respectively) and inhibits Class III HDAC isoforms at nanomolar concentrations. |
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| Molecular Formula | C21H23N5O2 |
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| Molecular Weight | 377.44 |
| InChIKey | MTAWGBVDXCFYOF-UHFFFAOYSA-N |
| SMILES | O=C(NO)c1ccc(Cn2cc(-c3ccc(CN4CCCC4)cc3)nn2)cc1 |