126766-31-2

126766-31-2 structure

126766-31-2 structure

Name: GR 89696 free base
Chemical Name: GR 89696 free base
CAS Number: 126766-31-2
Molecular Formula: C₁₉H₂₅Cl₂N₃O₃
Molecular Weight: 414.33
Catalog: Signaling Pathways GPCR/G Protein Opioid Receptor
Create Date: 2023-06-09 17:09:32
Modify Date: 2024-01-17 19:09:05
GR 89696 free base is a highly selective κ2 opioid receptor agonist with potential to prevent pruritus[1].

Name	GR 89696 free base

Description	GR 89696 free base is a highly selective κ2 opioid receptor agonist with potential to prevent pruritus[1].
Related Catalog	Signaling Pathways >> GPCR/G Protein >> Opioid Receptor Research Areas >> Inflammation/Immunology Signaling Pathways >> Neuronal Signaling >> Opioid Receptor
In Vivo	GR 89696 free base (肌内注射, 0.01-0.1 μg/kg) 剂量依赖性减弱鞘内注射吗啡 (0.03 mg) 诱导的抓挠反应而不影响吗啡的镇痛作用[1]。 GR-896960 free base (皮下注射，1 mg/kg) 在永久性局灶性缺血大鼠模型中将脑动脉梗塞体积减少 38%[2]。
References	[1]. Mei-Chuan Ko, et al. Effects of atypical kappa-opioid receptor agonists on intrathecal morphine-induced itch and analgesia in primates. J Pharmacol Exp Ther. 2009 Jan;328(1):193-200. [2]. A Barber, et al. Effects of GR-89696 and the novel peripherally selective OP2 agonists, EMD-61569 and EMD-61747, against focal cerebral ischemia in the rat. Methods Find Exp Clin Pharmacol. 1999 Mar;21(2):105-13

Molecular Formula	C₁₉H₂₅Cl₂N₃O₃
Molecular Weight	414.33