1267502-34-0
1267502-34-0 structure
- Name: FNDR-20123 free base
- Chemical Name: FNDR-20123 free base
- CAS Number: 1267502-34-0
- Molecular Formula: C21H23N5O2
- Molecular Weight: 377.44
- Create Date: 2021-09-12 20:56:18
- Modify Date: 2024-04-11 19:41:06
-
FNDR-20123 free base is an orally active, safe and a first-in-class anti-malarial HDAC inhibitor with IC50s of 31 nM and 3 nM for Plasmodium and human HDAC, respectively. FNDR-20123 free base exerts anti-malarial activity against Plasmodium falciparum asexual stage (IC50=41 nM) and sexual blood stage (IC50=190 nM for male gametocytes). FNDR-20123 free base inhibits HDAC1, HDAC2, HDAC3, HDAC6, and HDAC8 (IC50=25, 29, 2, 11, and 282 nM, respectively) and inhibits Class III HDAC isoforms at nanomolar concentrations.
| Name | FNDR-20123 free base |
|---|
| Description | FNDR-20123 free base is an orally active, safe and a first-in-class anti-malarial HDAC inhibitor with IC50s of 31 nM and 3 nM for Plasmodium and human HDAC, respectively. FNDR-20123 free base exerts anti-malarial activity against Plasmodium falciparum asexual stage (IC50=41 nM) and sexual blood stage (IC50=190 nM for male gametocytes). FNDR-20123 free base inhibits HDAC1, HDAC2, HDAC3, HDAC6, and HDAC8 (IC50=25, 29, 2, 11, and 282 nM, respectively) and inhibits Class III HDAC isoforms at nanomolar concentrations. |
|---|
| Molecular Formula | C21H23N5O2 |
|---|---|
| Molecular Weight | 377.44 |