1285702-20-6
1285702-20-6 structure
- Name: ML-167
- Chemical Name: 5-[4-[[(5-Methyl-2-furanyl)methyl]amino]-6-quinazolinyl]-2-furanmethanol
- CAS Number: 1285702-20-6
- Molecular Formula: C19H17N3O3
- Molecular Weight: 335.357
- Catalog: Biochemical Inhibitor Cell Cycle CDK inhibitor
- Create Date: 2017-11-16 12:09:09
- Modify Date: 2024-01-23 12:49:37
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ML167 is a highly selective Cdc2-like kinase 4 (Clk4) inhibitor with IC50 of 136 nM, >10-fold selectivity for closely related kinases Clk1, Clk2, Clk3 and Dyrk1A/1B.
| Name | 5-[4-[[(5-Methyl-2-furanyl)methyl]amino]-6-quinazolinyl]-2-furanmethanol |
|---|---|
| Synonyms |
[5-(4-{[(5-Methyl-2-furyl)methyl]amino}-6-quinazolinyl)-2-furyl]methanol
2-Furanmethanol, 5-[4-[[(5-methyl-2-furanyl)methyl]amino]-6-quinazolinyl]- [5-[4-[methyl-(5-methylfuran-2-yl)amino]quinazolin-6-yl]furan-2-yl]methanol ML167 |
| Description | ML167 is a highly selective Cdc2-like kinase 4 (Clk4) inhibitor with IC50 of 136 nM, >10-fold selectivity for closely related kinases Clk1, Clk2, Clk3 and Dyrk1A/1B. |
|---|---|
| Related Catalog | |
| Target |
Clk4:136 nM (IC50) CLK1:1522 nM (IC50) Clk2:1648 nM (IC50) Dyrk1B:4420 nM (IC50) |
| References |
[1]. Rosenthal AS, et al. An inhibitor of the Cdc2-like kinase 4 (Clk4). |
| Density | 1.3±0.1 g/cm3 |
|---|---|
| Boiling Point | 531.8±45.0 °C at 760 mmHg |
| Molecular Formula | C19H17N3O3 |
| Molecular Weight | 335.357 |
| Flash Point | 275.4±28.7 °C |
| Exact Mass | 335.126984 |
| PSA | 75.53000 |
| LogP | 2.68 |
| Appearance | off-white to gray to brown |
| Vapour Pressure | 0.0±1.5 mmHg at 25°C |
| Index of Refraction | 1.679 |
| Storage condition | ?20°C |
| Water Solubility | DMSO: soluble10mg/mL, clear |
