ML 190

Modify Date: 2024-01-13 14:10:28

ML 190 structure	Common Name	ML 190
	CAS Number	1355244-02-8	Molecular Weight	488.58
	Density	N/A	Boiling Point	N/A
	Molecular Formula	C₂₇H₃₂N₆O₃	Melting Point	N/A
	MSDS	N/A	Flash Point	N/A

Use of ML 190

ML 190 is a selective κ opioid receptor (KOR) antagonist with an IC50 of 120 nM and an EC50 of 129 nM, respectively[1].

Name	N-(3-(4-(4-methoxyphenyl)piperazin-1-yl)propyl)-2-(1-methyl-6-oxopyrido[2,3-e]pyrrolo[1,2-a]pyrazin-5(6H)-yl)acetamide
Synonym	More Synonyms

Description	ML 190 is a selective κ opioid receptor (KOR) antagonist with an IC50 of 120 nM and an EC50 of 129 nM, respectively[1].
Related Catalog	Signaling Pathways >> GPCR/G Protein >> Opioid Receptor Signaling Pathways >> Neuronal Signaling >> Opioid Receptor Research Areas >> Neurological Disease
Target	IC50: 120 nM (KOR)[1] EC50: 129 nM (KOR)[1]
In Vitro	ML 190 exhibits plasma protein binding of 93.96% (1 μM), 88.54% (10 μM) in human and 88.46% (1 μM), 80.07% (10 μM) in mouse, respectively; plasma remaining percents of 100% at 3 hours in both human and mouse; hepatic microsome remaining percents of 22.13% and 7.34% at 1 hour in human and mouse, respectively; and hepatic toxicity LC50 over 50 μM[1].
References	[1]. Frankowski KJ, et al. Discovery of Small Molecule Kappa Opioid Receptor Agonist and Antagonist Chemotypes through a HTS and Hit Refinement Strategy. ACS Chem Neurosci. 2012;3(3):221-236.

Molecular Formula	C₂₇H₃₂N₆O₃
Molecular Weight	488.58
Exact Mass	488.25400
PSA	84.11000
LogP	2.68850

ML 190

GMQ hydrochloride

Shanghai Nianxing Industrial Co., Ltd
China
Product Name: ML 190
Price: Check
Purity: 98.0%
Delivery: 10 Day
Contact: Yang
Email: sales@echemcloud.com

DC Chemicals Limited
China
Product Name: ML190
Price: $550.0/100mg $850.0/250mg $1800.0/1g
Purity: 98.0%
Delivery: 3 Day
Contact: Tony Cao
Email: sales@dcchemicals.com

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