ML-109

Names

[ CAS No. ]:
1186649-91-1

[ Name ]:
ML-109

Biological Activity

[Description]:

ML-109 is a potent and full thyroid stimulating hormone receptor (TSHR) agonist, with an EC50 of 40 nM.

[Related Catalog]:

Signaling Pathways >> GPCR/G Protein >> TSH Receptor

Research Areas >> Metabolic Disease

[Target]

EC50: 40 nM (TSHR)[1].

[In Vitro]

ML-109 (Compound 2) is a full agonist at TSHR with an EC50 of 40 nM and, like compound 1, it has no activity at FSHR or LHCGR. ML-109 contains an aminal, a functional group that is subject to hydrolysis and/or other degradation mechanisms. ML-109 is surprisingly stable at neutral and basic conditions (t1/2 of ~16 h) but is found to degrade at low pH (t1/2 of ~3 h)[1].

[References]

[1]. Neumann S, et al. Small-molecule agonists for the thyrotropin receptor stimulate thyroid function in human thyrocytes and mice. Proc Natl Acad Sci U S A. 2009 Jul 28;106(30):12471-6.

[Related Small Molecules]

ML-224 | Org41841

Chemical & Physical Properties

[ Molecular Formula ]:
C₃₁H₂₉N₃O₅

[ Molecular Weight ]:
523.58

[ Storage condition ]:
2-8℃

Related Compounds

The content on this webpage is sourced from various professional data sources. If you have any questions or concerns regarding the content, please feel free to contact service1@chemsrc.com.