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ML 792

Names

[ CAS No. ]:
1644342-14-2

[ Name ]:
ML 792

[Synonym ]:
Sulfamic acid, [(1R,2S,4R)-4-[[5-[[1-[(3-bromophenyl)methyl]-1H-pyrazol-3-yl]carbonyl]-4-pyrimidinyl]amino]-2-hydroxycyclopentyl]methyl ester
{(1R,2S,4R)-4-[(5-{[1-(3-Bromobenzyl)-1H-pyrazol-3-yl]carbonyl}-4-pyrimidinyl)amino]-2-hydroxycyclopentyl}methyl sulfamate

Biological Activity

[Description]:

ML 792 is a potent, seletive SUMO-activating enzyme (SAE) inhibitor with IC50 of 3 nM and 11 nM for SAE/SUMO1 and SAE/SUMO2, respectively; shows no significant inhibition for closely related E1 enzymes NAE (IC50=32 uM) and ubiquitin-activating enzyme (UAE) (IC50 >100 uM), as well as a panel of 366 ATP-using enzymes; dose-dependently decreases global SUMOylation in HCT116 cells (EC50=19 nM), demonstrates potent antiproliferative effect in HCT116 cells and MDA-MB-231 cells with EC50 of 0.04 and 0.11 uM, respectively.

[References]

References 1. He X, et al. Nat Chem Biol. 2017 Sep 11. doi: 10.1038/nchembio.2463. View Related Products by Target Ubiquitin-activating Enzyme (E1)

Chemical & Physical Properties

[ Density]:
1.7±0.1 g/cm3

[ Boiling Point ]:
815.1±75.0 °C at 760 mmHg

[ Molecular Formula ]:
C21H23BrN6O5S

[ Molecular Weight ]:
551.414

[ Flash Point ]:
446.7±37.1 °C

[ Exact Mass ]:
550.063416

[ LogP ]:
1.71

[ Vapour Pressure ]:
0.0±3.1 mmHg at 25°C

[ Index of Refraction ]:
1.740

Related Compounds