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ML-​226

Names

[ CAS No. ]:
2055172-43-3

[ Name ]:
ML-​226

[Synonym ]:
ML-226
Methanone, (2-ethyl-1-piperidinyl)[4-(hydroxydiphenylmethyl)-2H-1,2,3-triazol-2-yl]-
(2-Ethyl-1-piperidinyl){4-[hydroxy(diphenyl)methyl]-2H-1,2,3-triazol-2-yl}methanone

Biological Activity

[Description]:

ML226 is a potent α/β hydrolase domain-containing protein 11 (ABHD11) inhibitor in vitro and in situ with IC50s of 15 and 0.68 nM, respectively[1].

[Related Catalog]:

Signaling Pathways >> Metabolic Enzyme/Protease >> MAGL
Research Areas >> Neurological Disease

[References]

[1]. Hsu KL, et al. Optimization and characterization of triazole urea inhibitors for abhydrolase domain containing protein 6 (ABHD6). 2012 Apr 12 [updated 2013 Mar 14]. In: Probe Reports from the NIH Molecular Libraries Program [Internet]. Bethesda (MD): National Center for Biotechnology Information (US); 2010–.

Chemical & Physical Properties

[ Density]:
1.2±0.1 g/cm3

[ Boiling Point ]:
576.8±42.0 °C at 760 mmHg

[ Molecular Formula ]:
C23H26N4O2

[ Molecular Weight ]:
390.478

[ Flash Point ]:
302.7±27.9 °C

[ Exact Mass ]:
390.205566

[ LogP ]:
3.17

[ Vapour Pressure ]:
0.0±1.7 mmHg at 25°C

[ Index of Refraction ]:
1.637

Related Compounds