ML-243

Names

[ Name ]:
ML-243

[Synonym ]:
(2E)-N-(4,5-Dihydro-1,3-thiazol-2-yl)-3-(4-ethylphenyl)acrylamide
2-Propenamide, N-(4,5-dihydro-2-thiazolyl)-3-(4-ethylphenyl)-, (2E)-
Streptomyces metabolite 2880 II
2880-II

Biological Activity

[Description]:

ML243 is a selective small-molecule inhibitor of breast cancer stem cells. ML243 has 32-fold greater selective inhibition in the breast CSC-like cell line HMLE_shECad than the control cell line HMLE_shGFP[1].

[Related Catalog]:

Research Areas >> Cancer

Signaling Pathways >> Others >> Others

[Target]

Breast CSCs[1]

[References]

[1]. Carmody L, et al. Identification of a Selective Small-Molecule Inhibitor of Breast Cancer Stem Cells - Probe 3. 2011 Sep 28 [updated 2013 Mar 7].

Chemical & Physical Properties

[ Density]:
1.2±0.1 g/cm3

[ Molecular Formula ]:
C₁₄H₁₆N₂OS

[ Molecular Weight ]:
260.355

[ Exact Mass ]:
260.098328

[ PSA ]:
70.25000

[ LogP ]:
2.65

[ Index of Refraction ]:
1.608

Safety Information

[ Symbol ]:

GHS07

[ Signal Word ]:
Warning

[ Hazard Statements ]:
H302

[ Precautionary Statements ]:
P301 + P312 + P330

[ RIDADR ]:
NONH for all modes of transport

Synthetic Route

Click to get detail synthetic route

Related Compounds

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