ML-209

Names

[ Name ]:
ML-209

[Synonym ]:
3-(1,3-Benzodioxol-5-yl)-1-[(3R,5S)-3,5-dimethyl-1-piperidinyl]-3-(2-hydroxy-4,6-dimethoxyphenyl)-1-propanone
ML-209
1-Propanone, 3-(1,3-benzodioxol-5-yl)-1-[(3R,5S)-3,5-dimethyl-1-piperidinyl]-3-(2-hydroxy-4,6-dimethoxyphenyl)-

Biological Activity

[Description]:

(±)-ML 209 (compound 4n), a diphenylpropanamide, is a retinoic acid-related orphan receptor RORγ antagonist with an IC50 of 1.1 μM. (±)-ML 209 inhibits RORγt transcriptional activity with an IC50 of 300 nM in HEK293t cells. (±)-ML 209 inhibits the transcriptional activity of RORγt, but not RORα in cells. (±)-ML 209 selectively inhibits murine Th17 cell differentiation without affecting the differentiation of naïve CD4+ T cells into other lineages, including Th1 and regulatory T cells[1].

[Related Catalog]:

Signaling Pathways >> Metabolic Enzyme/Protease >> ROR

Research Areas >> Inflammation/Immunology

[Target]

RORγ:1.1 μM (IC50)

[References]

[1]. Jun R Huh, et al. Identification of Potent and Selective Diphenylpropanamide RORγ Inhibitors. ACS Med Chem Lett. 2013 Jan 10;4(1):79-84.

Chemical & Physical Properties

[ Density]:
1.2±0.1 g/cm3

[ Boiling Point ]:
656.2±55.0 °C at 760 mmHg

[ Molecular Formula ]:
C₂₅H₃₁NO₆

[ Molecular Weight ]:
441.52

[ Flash Point ]:
350.7±31.5 °C

[ Exact Mass ]:
441.215149

[ LogP ]:
4.66

[ Vapour Pressure ]:
0.0±2.0 mmHg at 25°C

[ Index of Refraction ]:
1.568

Related Compounds

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