ML 210
Modify Date: 2025-08-25 12:16:58
ML 210 structure
|
Common Name | ML 210 | ||
|---|---|---|---|---|
| CAS Number | 1360705-96-9 | Molecular Weight | 475.325 | |
| Density | 1.4±0.1 g/cm3 | Boiling Point | 644.7±55.0 °C at 760 mmHg | |
| Molecular Formula | C22H20Cl2N4O4 | Melting Point | N/A | |
| MSDS | Chinese USA | Flash Point | 343.7±31.5 °C | |
| Symbol |
GHS07 |
Signal Word | Warning | |
Use of ML 210ML-210，the most potent compound in the nitroisoxazole series， is a selective covalent inhibitor of glutathione peroxidase 4 (GPX4) by binding the selenocysteine residue[1]. ML-210 has IC50s of 71 nM, 272 nM and 107nM for BJeLR (HRASV12), BJeH-LT (without HRASV12) and DRD cell lines, respectively[2]. |
| Name | {4-[Bis(4-chlorophenyl)methyl]-1-piperazinyl}(5-methyl-4-nitro-1,2-oxazol-3-yl)methanone |
|---|---|
| Synonym | More Synonyms |
| Description | ML-210，the most potent compound in the nitroisoxazole series， is a selective covalent inhibitor of glutathione peroxidase 4 (GPX4) by binding the selenocysteine residue[1]. ML-210 has IC50s of 71 nM, 272 nM and 107nM for BJeLR (HRASV12), BJeH-LT (without HRASV12) and DRD cell lines, respectively[2]. |
|---|---|
| Related Catalog | |
| Target |
Glutathione Peroxidase 4 (GPX4)[1] |
| References |
| Density | 1.4±0.1 g/cm3 |
|---|---|
| Boiling Point | 644.7±55.0 °C at 760 mmHg |
| Molecular Formula | C22H20Cl2N4O4 |
| Molecular Weight | 475.325 |
| Flash Point | 343.7±31.5 °C |
| Exact Mass | 474.086151 |
| LogP | 2.39 |
| Vapour Pressure | 0.0±1.9 mmHg at 25°C |
| Index of Refraction | 1.636 |
| T6N DNTJ AYR DG&R DG& DV- ET5NOJ C1 DNW |
| MFCD22666407 |
| Methanone, [4-[bis(4-chlorophenyl)methyl]-1-piperazinyl](5-methyl-4-nitro-3-isoxazolyl)- |
| [4-[Bis(4-chlorophenyl)methyl]-1-piperazinyl]-(5-methyl-4-nitro-3-isoxazolyl)methanone |
| {4-[Bis(4-chlorophenyl)methyl]-1-piperazinyl}(5-methyl-4-nitro-1,2-oxazol-3-yl)methanone |