ML 210

Modify Date: 2024-01-02 20:18:49

ML 210 structure	Common Name	ML 210
	CAS Number	1360705-96-9	Molecular Weight	475.325
	Density	1.4±0.1 g/cm3	Boiling Point	644.7±55.0 °C at 760 mmHg
	Molecular Formula	C₂₂H₂₀Cl₂N₄O₄	Melting Point	N/A
	MSDS	Chinese USA	Flash Point	343.7±31.5 °C
	Symbol	GHS07	Signal Word	Warning

Use of ML 210

ML-210，the most potent compound in the nitroisoxazole series， is a selective covalent inhibitor of glutathione peroxidase 4 (GPX4) by binding the selenocysteine residue[1]. ML-210 has IC50s of 71 nM, 272 nM and 107nM for BJeLR (HRASV12), BJeH-LT (without HRASV12) and DRD cell lines, respectively[2].

Name	{4-[Bis(4-chlorophenyl)methyl]-1-piperazinyl}(5-methyl-4-nitro-1,2-oxazol-3-yl)methanone
Synonym	More Synonyms

Description	ML-210，the most potent compound in the nitroisoxazole series， is a selective covalent inhibitor of glutathione peroxidase 4 (GPX4) by binding the selenocysteine residue[1]. ML-210 has IC50s of 71 nM, 272 nM and 107nM for BJeLR (HRASV12), BJeH-LT (without HRASV12) and DRD cell lines, respectively[2].
Related Catalog	Research Areas >> Cancer
Target	Glutathione Peroxidase 4 (GPX4)[1]
References	[1]. John K. Eaton, et al. Targeting a Therapy-Resistant Cancer Cell State Using Masked Electrophiles as GPX4 Inhibitors. Biorxiv. 2018. [2]. Weïwer M, et al. Development of small-molecule probes that selectively kill cells induced to express mutant RAS. Bioorg Med Chem Lett. 2012 Feb 15;22(4):1822-6.

Density	1.4±0.1 g/cm3
Boiling Point	644.7±55.0 °C at 760 mmHg
Molecular Formula	C₂₂H₂₀Cl₂N₄O₄
Molecular Weight	475.325
Flash Point	343.7±31.5 °C
Exact Mass	474.086151
LogP	2.39
Vapour Pressure	0.0±1.9 mmHg at 25°C
Index of Refraction	1.636

Symbol	GHS07
Signal Word	Warning
Hazard Statements	H302
RIDADR	NONH for all modes of transport

T6N DNTJ AYR DG&R DG& DV- ET5NOJ C1 DNW

MFCD22666407

Methanone, [4-[bis(4-chlorophenyl)methyl]-1-piperazinyl](5-methyl-4-nitro-3-isoxazolyl)-

[4-[Bis(4-chlorophenyl)methyl]-1-piperazinyl]-(5-methyl-4-nitro-3-isoxazolyl)methanone

{4-[Bis(4-chlorophenyl)methyl]-1-piperazinyl}(5-methyl-4-nitro-1,2-oxazol-3-yl)methanone

DC Chemicals Limited
China
Product Name: ML-210
Price: $Inquiry/25mg $Inquiry/100mg $Inquiry/250mg
Purity: 98.0%
Stocking Period: 3 Day
Contact: Tony Cao

Dayang Chem (Hangzhou) Co., Ltd.
China
Product Name: [4-[Bis(4-chlorophenyl)methyl]piperazin-1-yl]-(5-methyl-4-nitro-1,2-oxazol-3-yl)methanone
Price: $Inquiry/100g $Inquiry/1kg $Inquiry/100kg $Inquiry/1000kg
Purity: 98.0%
Stocking Period: Inquiry
Contact: Ms Wang

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