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ML 210

Names

[ CAS No. ]:
1360705-96-9

[ Name ]:
ML 210

[Synonym ]:
T6N DNTJ AYR DG&R DG& DV- ET5NOJ C1 DNW
MFCD22666407
Methanone, [4-[bis(4-chlorophenyl)methyl]-1-piperazinyl](5-methyl-4-nitro-3-isoxazolyl)-
[4-[Bis(4-chlorophenyl)methyl]-1-piperazinyl]-(5-methyl-4-nitro-3-isoxazolyl)methanone
{4-[Bis(4-chlorophenyl)methyl]-1-piperazinyl}(5-methyl-4-nitro-1,2-oxazol-3-yl)methanone

Biological Activity

[Description]:

ML-210，the most potent compound in the nitroisoxazole series， is a selective covalent inhibitor of glutathione peroxidase 4 (GPX4) by binding the selenocysteine residue[1]. ML-210 has IC50s of 71 nM, 272 nM and 107nM for BJeLR (HRASV12), BJeH-LT (without HRASV12) and DRD cell lines, respectively[2].

[Related Catalog]:

Research Areas >> Cancer

[Target]

Glutathione Peroxidase 4 (GPX4)[1]


[References]

[1]. John K. Eaton, et al. Targeting a Therapy-Resistant Cancer Cell State Using Masked Electrophiles as GPX4 Inhibitors. Biorxiv. 2018.

[2]. Weïwer M, et al. Development of small-molecule probes that selectively kill cells induced to express mutant RAS. Bioorg Med Chem Lett. 2012 Feb 15;22(4):1822-6.

Chemical & Physical Properties

[ Density]:
1.4±0.1 g/cm3

[ Boiling Point ]:
644.7±55.0 °C at 760 mmHg

[ Molecular Formula ]:
C22H20Cl2N4O4

[ Molecular Weight ]:
475.325

[ Flash Point ]:
343.7±31.5 °C

[ Exact Mass ]:
474.086151

[ LogP ]:
2.39

[ Vapour Pressure ]:
0.0±1.9 mmHg at 25°C

[ Index of Refraction ]:
1.636

Safety Information

[ Symbol ]:

GHS07

[ Signal Word ]:
Warning

[ Hazard Statements ]:
H302

[ RIDADR ]:
NONH for all modes of transport

Related Compounds