ML 792

Names

[ Name ]:
ML 792

[Synonym ]:
Sulfamic acid, [(1R,2S,4R)-4-[[5-[[1-[(3-bromophenyl)methyl]-1H-pyrazol-3-yl]carbonyl]-4-pyrimidinyl]amino]-2-hydroxycyclopentyl]methyl ester
{(1R,2S,4R)-4-[(5-{[1-(3-Bromobenzyl)-1H-pyrazol-3-yl]carbonyl}-4-pyrimidinyl)amino]-2-hydroxycyclopentyl}methyl sulfamate

Biological Activity

[Description]:

ML 792 is a potent, seletive SUMO-activating enzyme (SAE) inhibitor with IC50 of 3 nM and 11 nM for SAE/SUMO1 and SAE/SUMO2, respectively; shows no significant inhibition for closely related E1 enzymes NAE (IC50=32 uM) and ubiquitin-activating enzyme (UAE) (IC50 >100 uM), as well as a panel of 366 ATP-using enzymes; dose-dependently decreases global SUMOylation in HCT116 cells (EC50=19 nM), demonstrates potent antiproliferative effect in HCT116 cells and MDA-MB-231 cells with EC50 of 0.04 and 0.11 uM, respectively.

[References]

References 1. He X, et al. Nat Chem Biol. 2017 Sep 11. doi: 10.1038/nchembio.2463. View Related Products by Target Ubiquitin-activating Enzyme (E1)

Chemical & Physical Properties

[ Density]:
1.7±0.1 g/cm3

[ Boiling Point ]:
815.1±75.0 °C at 760 mmHg

[ Molecular Formula ]:
C₂₁H₂₃BrN₆O₅S

[ Molecular Weight ]:
551.414

[ Flash Point ]:
446.7±37.1 °C

[ Exact Mass ]:
550.063416

[ LogP ]:
1.71

[ Vapour Pressure ]:
0.0±3.1 mmHg at 25°C

[ Index of Refraction ]:
1.740

Related Compounds

The content on this webpage is sourced from various professional data sources. If you have any questions or concerns regarding the content, please feel free to contact service1@chemsrc.com.