Propargyl-PEG2-methylamine

Modify Date: 2022-01-15 18:46:48

Propargyl-PEG2-methylamine Structure
Propargyl-PEG2-methylamine structure
Common Name Propargyl-PEG2-methylamine
CAS Number 1835759-76-6 Molecular Weight 157.210
Density 0.9±0.1 g/cm3 Boiling Point 214.6±20.0 °C at 760 mmHg
Molecular Formula C8H15NO2 Melting Point N/A
MSDS N/A Flash Point 83.6±11.2 °C

 Use of Propargyl-PEG2-methylamine


Propargyl-PEG2-methylamine is a PEG derivative containing a propargyl group and methylamine group. The propargyl group can be reacted with azide-bearing compounds or biomolecules via copper catalyzed azide-alkyne Click Chemistry to yield a stable triazole linkage. The methylamine group is reactive with carboxylic acids, activated NHS esters, carbonyls (ketone, aldehyde) etc. PEG Linkers are useful in the development of antibody drug conjugates.

 Names

Name N-Methyl-2-[2-(2-propyn-1-yloxy)ethoxy]ethanamine
Synonym More Synonyms

 Chemical & Physical Properties

Density 0.9±0.1 g/cm3
Boiling Point 214.6±20.0 °C at 760 mmHg
Molecular Formula C8H15NO2
Molecular Weight 157.210
Flash Point 83.6±11.2 °C
Exact Mass 157.110275
LogP -0.16
Vapour Pressure 0.2±0.4 mmHg at 25°C
Index of Refraction 1.444

 Synonyms

Ethanamine, N-methyl-2-[2-(2-propyn-1-yloxy)ethoxy]-
MFCD29042339
N-Methyl-2-[2-(2-propyn-1-yloxy)ethoxy]ethanamine
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