Propargyl-PEG2-NHBoc
Modify Date: 2024-01-13 16:24:25
Propargyl-PEG2-NHBoc structure
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Common Name | Propargyl-PEG2-NHBoc | ||
|---|---|---|---|---|
| CAS Number | 869310-84-9 | Molecular Weight | 243.29900 | |
| Density | N/A | Boiling Point | N/A | |
| Molecular Formula | C12H21NO4 | Melting Point | N/A | |
| MSDS | N/A | Flash Point | N/A | |
Use of Propargyl-PEG2-NHBocPropargyl-PEG2-NHBoc is a cleavable ADC linker used in the synthesis of antibody-drug conjugates (ADCs). Propargyl-PEG2-NHBoc is a PEG-based PROTAC linker can be used in the synthesis of PROTACs[1]. |
| Name | tert-butyl 2-(2-(prop-2-ynyloxy)ethoxy)ethylcarbamate |
|---|---|
| Synonym | More Synonyms |
| Description | Propargyl-PEG2-NHBoc is a cleavable ADC linker used in the synthesis of antibody-drug conjugates (ADCs). Propargyl-PEG2-NHBoc is a PEG-based PROTAC linker can be used in the synthesis of PROTACs[1]. |
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| Related Catalog | |
| Target |
Cleavable PEGs Alkyl/ether |
| In Vitro | ADCs are comprised of an antibody to which is attached an ADC cytotoxin through an ADC linker. PROTACs contain two different ligands connected by a linker; one is a ligand for an E3 ubiquitin ligase and the other is for the target protein. PROTACs exploit the intracellular ubiquitin-proteasome system to selectively degrade target proteins. |
| References |
[1]. Nello Mainolfi, et al. rak degraders and uses thereof. US20190192668A1. |
| Molecular Formula | C12H21NO4 |
|---|---|
| Molecular Weight | 243.29900 |
| Exact Mass | 243.14700 |
| PSA | 56.79000 |
| LogP | 1.56840 |
| Storage condition | 2-8℃ |
| [2-(2-prop-2-ynyloxy)-ethyl]-carbamic acid tert.-butyl ester |
| [2-(2-prop-2-ynyloxy-ethoxy)-ethyl]-carbamic acid tert-butyl ester |
| [2-(2-Prop-2-ynyloxy-ethoxy)-ethyl]-carbamic acid tert-butyl ester |