869310-84-9
869310-84-9 structure
- Name: Propargyl-PEG2-NHBoc
- Chemical Name: tert-butyl 2-(2-(prop-2-ynyloxy)ethoxy)ethylcarbamate
- CAS Number: 869310-84-9
- Molecular Formula: C12H21NO4
- Molecular Weight: 243.29900
- Catalog: Signaling Pathways Antibody-drug Conjugate ADC Linker
- Create Date: 2018-04-09 10:13:48
- Modify Date: 2024-01-13 16:24:25
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Propargyl-PEG2-NHBoc is a cleavable ADC linker used in the synthesis of antibody-drug conjugates (ADCs). Propargyl-PEG2-NHBoc is a PEG-based PROTAC linker can be used in the synthesis of PROTACs[1].
| Name | tert-butyl 2-(2-(prop-2-ynyloxy)ethoxy)ethylcarbamate |
|---|---|
| Synonyms |
[2-(2-prop-2-ynyloxy)-ethyl]-carbamic acid tert.-butyl ester
[2-(2-prop-2-ynyloxy-ethoxy)-ethyl]-carbamic acid tert-butyl ester [2-(2-Prop-2-ynyloxy-ethoxy)-ethyl]-carbamic acid tert-butyl ester |
| Description | Propargyl-PEG2-NHBoc is a cleavable ADC linker used in the synthesis of antibody-drug conjugates (ADCs). Propargyl-PEG2-NHBoc is a PEG-based PROTAC linker can be used in the synthesis of PROTACs[1]. |
|---|---|
| Related Catalog | |
| Target |
Cleavable PEGs Alkyl/ether |
| In Vitro | ADCs are comprised of an antibody to which is attached an ADC cytotoxin through an ADC linker. PROTACs contain two different ligands connected by a linker; one is a ligand for an E3 ubiquitin ligase and the other is for the target protein. PROTACs exploit the intracellular ubiquitin-proteasome system to selectively degrade target proteins. |
| References |
[1]. Nello Mainolfi, et al. rak degraders and uses thereof. US20190192668A1. |
| Molecular Formula | C12H21NO4 |
|---|---|
| Molecular Weight | 243.29900 |
| Exact Mass | 243.14700 |
| PSA | 56.79000 |
| LogP | 1.56840 |
| Storage condition | 2-8℃ |