Propargyl-PEG2-Tos

Modify Date: 2024-01-08 09:26:44

Propargyl-PEG2-Tos Structure
Propargyl-PEG2-Tos structure
Common Name Propargyl-PEG2-Tos
CAS Number 145916-41-2 Molecular Weight 254.30200
Density N/A Boiling Point N/A
Molecular Formula C12H14O4S Melting Point N/A
MSDS N/A Flash Point N/A

 Use of Propargyl-PEG2-Tos


Propargyl-PEG2-Tos is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs[1].

 Names

Name 2-(prop-2-yn-1-yloxy)ethyl 4-methylbenzenesulfonate
Synonym More Synonyms

 Propargyl-PEG2-Tos Biological Activity

Description Propargyl-PEG2-Tos is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs[1].
Related Catalog
Target

PEGs

In Vitro PROTACs contain two different ligands connected by a linker; one is a ligand for an E3 ubiquitin ligase and the other is for the target protein. PROTACs exploit the intracellular ubiquitin-proteasome system to selectively degrade target proteins[1].
References

[1]. An S, et al. Small-molecule PROTACs: An emerging and promising approach for the development of targeted therapy drugs. EBioMedicine. 2018 Oct;36:553-562

 Chemical & Physical Properties

Molecular Formula C12H14O4S
Molecular Weight 254.30200
Exact Mass 254.06100
PSA 60.98000
LogP 2.43090

 Synonyms

2-(2-propynyloxy)ethanol p-toluenesulfonate
2-(propargyloxy)ethyl p-toluenesulfonate
3-oxohex-5-ynyl tosylate
2-(2-propynyloxy)ethyl tosylate
2-prop-2-ynyloxyethyl p-toluenesulfonate
2-(prop-2-ynyloxy)ethyl p-toluenesulfonate