BMS-986163

Modify Date: 2024-02-08 21:58:17

BMS-986163 Structure
BMS-986163 structure
Common Name BMS-986163
CAS Number 1801151-09-6 Molecular Weight 462.45
Density N/A Boiling Point N/A
Molecular Formula C23H28FN2O5P Melting Point N/A
MSDS N/A Flash Point N/A

 Use of BMS-986163


BMS-986163 is a negative allosteric modulator of GluN2B. The prodrug BMS-986163 rapidly converts to its active parent molecule BMS-986169 (Ki=4 nM, IC50=24 nM).

 Names

Name BMS-986163

 BMS-986163 Biological Activity

Description BMS-986163 is a negative allosteric modulator of GluN2B. The prodrug BMS-986163 rapidly converts to its active parent molecule BMS-986169 (Ki=4 nM, IC50=24 nM).
Related Catalog
Target

IC50: 4 nM (GluN2B, BMS-986169), 24 nM (GluN2B, BMS-986169)[1]

References

[1]. Marcin LR, et al. BMS-986163, a Negative Allosteric Modulator of GluN2B with Potential Utility in Major Depressive Disorder. ACS Med Chem Lett. 2018 Apr 13;9(5):472-477.

 Chemical & Physical Properties

Molecular Formula C23H28FN2O5P
Molecular Weight 462.45