1174046-72-0

1174046-72-0 structure

Name: BMS-794833
Chemical Name: N-[4-(2-amino-3-chloropyridin-4-yl)oxy-3-fluorophenyl]-5-(4-fluorophenyl)-4-oxo-1H-pyridine-3-carboxamide
CAS Number: 1174046-72-0
Molecular Formula: C₂₃H₁₅ClF₂N₄O₃
Molecular Weight: 468.840
Catalog: Biochemical Inhibitor Protein tyrosine kinase
Create Date: 2019-01-01 20:12:44
Modify Date: 2024-01-21 12:31:18
BMS-794833 is a VEGFR2 and Met inhibitor extracted from patent WO2009094417, compound example 1; has IC50s of 15 and 1.7 nM, respectively.

Name	N-[4-(2-amino-3-chloropyridin-4-yl)oxy-3-fluorophenyl]-5-(4-fluorophenyl)-4-oxo-1H-pyridine-3-carboxamide
Synonyms	3-Pyridinecarboxamide, N-[4-[(2-amino-3-chloro-4-pyridinyl)oxy]-3-fluorophenyl]-5-(4-fluorophenyl)-1,4-dihydro-4-oxo- N-{4-[(2-Amino-3-chloro-4-pyridinyl)oxy]-3-fluorophenyl}-5-(4-fluorophenyl)-4-oxo-1,4-dihydro-3-pyridinecarboxamide BMS-794833

Description	BMS-794833 is a VEGFR2 and Met inhibitor extracted from patent WO2009094417, compound example 1; has IC50s of 15 and 1.7 nM, respectively.
Related Catalog	Signaling Pathways >> Protein Tyrosine Kinase/RTK >> c-Met/HGFR Research Areas >> Cancer
Target	VEGFR2:15 nM (IC50) Met:1.7 nM (IC50)
In Vitro	BMS794833 inhibits Met receptor activated gastric carcinoma cell line, GTL-16, with an IC50 of 39 nM[1].
In Vivo	BMS-794833 is active by greater than 50% tumor growth inhibition for at least one tumor doubling time in the GTL-16 gastric carcinoma model. No toxicity is observed at any of the dose levels when administered once daily for a duration of 14 days[1].
Cell Assay	GTL-16 cells are inoculated in to 96 well microtiter plates in 0.5% fetal calf serum and incubated at 37°C, 5% CO2, 95% air and 100% relative humidity for 24 h prior to addition of a compound. Cells are treated with BMS-794833 for an additional 72 h. Growth inhibition is calculated[1].
References	[1]. WO2009094417