2691796-83-3

2691796-83-3 structure

Name: BMS-1166-N-piperidine-CO-N-piperazine dihydrochloride
Chemical Name: BMS-1166-N-piperidine-CO-N-piperazine dihydrochloride
CAS Number: 2691796-83-3
Molecular Formula: C₄₁H₄₅Cl₃N₄O₅
Molecular Weight: 780.18
Catalog: Research Areas Cancer
Create Date: 2023-02-20 16:08:00
Modify Date: 2024-04-03 17:04:35
BMS-1166-N-piperidine-CO-N-piperazine dihydrochloride incorporates a ligand for PD-1/PD-L1 immune checkpoint, and a PROTAC linker. BMS-1166-N-piperidine-CO-N-piperazine dihydrochloride can be used in the synthesis of PD-1/PD-L1 degrader-1.html" class="link-product" target="_blank">PROTAC PD-1/PD-L1 degrader-1 (HY-131183). PROTAC PD-1/PD-L1 degrader-1 inhibits PD-1/PD-L1 interaction with an IC50 of 39.2 nM[1].

Name	BMS-1166-N-piperidine-CO-N-piperazine dihydrochloride

Description	BMS-1166-N-piperidine-CO-N-piperazine dihydrochloride incorporates a ligand for PD-1/PD-L1 immune checkpoint, and a PROTAC linker. BMS-1166-N-piperidine-CO-N-piperazine dihydrochloride can be used in the synthesis of PD-1/PD-L1 degrader-1.html" class="link-product" target="_blank">PROTAC PD-1/PD-L1 degrader-1 (HY-131183). PROTAC PD-1/PD-L1 degrader-1 inhibits PD-1/PD-L1 interaction with an IC50 of 39.2 nM[1].
Related Catalog	Research Areas >> Cancer
In Vitro	PROTAC 包含两个不同的配体，通过一个接头连接；一个是 E3 泛素连接酶的配体，另一个是靶蛋白的配体。PROTAC 利用细胞内泛素-蛋白酶体系统选择性降解靶蛋白[1]。
References	[1]. Cheng B, Ren Y, Cao H, Chen J. Discovery of novel resorcinol diphenyl ether-based PROTAC-like molecules as dual inhibitors and degraders of PD-L1. Eur J Med Chem. 2020;199:112377.

Molecular Formula	C₄₁H₄₅Cl₃N₄O₅
Molecular Weight	780.18