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BMS-986163

Names

[ CAS No. ]:
1801151-09-6

[ Name ]:
BMS-986163

Biological Activity

[Description]:

BMS-986163 is a negative allosteric modulator of GluN2B. The prodrug BMS-986163 rapidly converts to its active parent molecule BMS-986169 (Ki=4 nM, IC50=24 nM).

[Related Catalog]:

Signaling Pathways >> Neuronal Signaling >> iGluR
Research Areas >> Neurological Disease
Signaling Pathways >> Membrane Transporter/Ion Channel >> iGluR

[Target]

IC50: 4 nM (GluN2B, BMS-986169), 24 nM (GluN2B, BMS-986169)[1]


[References]

[1]. Marcin LR, et al. BMS-986163, a Negative Allosteric Modulator of GluN2B with Potential Utility in Major Depressive Disorder. ACS Med Chem Lett. 2018 Apr 13;9(5):472-477.

Chemical & Physical Properties

[ Molecular Formula ]:
C23H28FN2O5P

[ Molecular Weight ]:
462.45

Related Compounds