MI 14

Modify Date: 2024-01-14 23:32:59

MI 14 structure	Common Name	MI 14
	CAS Number	1715934-43-2	Molecular Weight	450.94
	Density	1.4±0.1 g/cm3	Boiling Point	N/A
	Molecular Formula	C₁₉H₂₃ClN₆O₃S	Melting Point	N/A
	MSDS	N/A	Flash Point	N/A

Use of MI 14

MI 14 is a selective PI4KIIIβ inhibitor with IC50s of 54 nM, >100 μM, >100 μM for PI4KIIIβ, PI4KIIIα, PI4KIIα, respectively. MI 14 has antiviral activity against HCV 1b, CVB3, HRVM, HVC 2a[1].

Name	MI 14
Synonym	More Synonyms

Description	MI 14 is a selective PI4KIIIβ inhibitor with IC50s of 54 nM, >100 μM, >100 μM for PI4KIIIβ, PI4KIIIα, PI4KIIα, respectively. MI 14 has antiviral activity against HCV 1b, CVB3, HRVM, HVC 2a[1].
Related Catalog	Signaling Pathways >> Anti-infection >> HCV Research Areas >> Infection Signaling Pathways >> PI3K/Akt/mTOR >> PI4K
Target	PI4KIIIβ:54 nM (IC50) PI4KIIIα:>100 μM (IC50) PI4KIIα:>100 μM (IC50)
In Vitro	MI 14 (化合物 36t) 对 HeLa 细胞中的 HCV 1b (EC50=0.087 µM)、CVB3 (EC50=0.145 µM)、HRVM (EC50=1.03 µM)、HVC 2a (EC50=10.6 µM) 具有抗病毒活性[1]。 MI 14 对磷脂酰肌醇 3 激酶 (PI3Ka、PI3Kb、PI3Kd 和 PI3Kg) 没有抑制作用，IC50 高达 10 µM[1]。
References	[1]. Ivana Mejdrová, et al. Highly Selective Phosphatidylinositol 4-Kinase IIIβ Inhibitors and Structural Insight into Their Mode of Action. J Med Chem. 2015 May 14;58(9):3767-93.

Density	1.4±0.1 g/cm3
Molecular Formula	C₁₉H₂₃ClN₆O₃S
Molecular Weight	450.94
Exact Mass	450.124084
LogP	1.97
Index of Refraction	1.661

N-[2-({6-Chloro-3-[3-(dimethylsulfamoyl)phenyl]-2-methylimidazo[1,2-b]pyridazin-8-yl}amino)ethyl]acetamide

MFCD29081194

N-[2-[[6-Chloro-3-[3-[(dimethylamino)sulfonyl]phenyl]-2-methylimidazo[1,2-b]pyridazin-8-yl]amino]ethyl]acetamide

Acetamide, N-[2-[[6-chloro-3-[3-[(dimethylamino)sulfonyl]phenyl]-2-methylimidazo[1,2-b]pyridazin-8-yl]amino]ethyl]-

MI 14

Use of MI 14

Names

MI 14 Biological Activity

Chemical & Physical Properties

Synonyms