1415340-63-4

1415340-63-4 structure

Name: MI-192 HCl
Chemical Name: N-(2-Aminophenyl)-4-[(4-methylene-1-oxo-3,4-dihydro-2(1H)-isoquinolinyl)methyl]benzamide
CAS Number: 1415340-63-4
Molecular Formula: C₂₄H₂₁N₃O₂
Molecular Weight: 383.44
Catalog: Signaling Pathways Apoptosis Apoptosis
Create Date: 2018-07-01 11:01:18
Modify Date: 2025-08-26 16:54:34
MI-192 is a selective HDAC2 and HDAC3 inhibitor with IC50s of 30 nM and 16 nM, respectively. MI-192 is more selective for HDAC2/3 than other HDAC isomers.MI-192 induces myeloid leukaemic cells apoptosis. Anticaner and neuroprotective activities[1][2].

Name	N-(2-Aminophenyl)-4-[(4-methylene-1-oxo-3,4-dihydro-2(1H)-isoquinolinyl)methyl]benzamide
Synonyms	Benzamide, N-(2-aminophenyl)-4-[(3,4-dihydro-4-methylene-1-oxo-2(1H)-isoquinolinyl)methyl]- N-(2-Aminophenyl)-4-[(4-methylene-1-oxo-3,4-dihydro-2(1H)-isoquinolinyl)methyl]benzamide MFCD30182338

Description	MI-192 is a selective HDAC2 and HDAC3 inhibitor with IC50s of 30 nM and 16 nM, respectively. MI-192 is more selective for HDAC2/3 than other HDAC isomers.MI-192 induces myeloid leukaemic cells apoptosis. Anticaner and neuroprotective activities[1][2].
Related Catalog	Signaling Pathways >> Apoptosis >> Apoptosis Research Areas >> Cancer Signaling Pathways >> Cell Cycle/DNA Damage >> HDAC Research Areas >> Neurological Disease Signaling Pathways >> Epigenetics >> HDAC
In Vitro	MI-192 (0.15-1 μM; 72 h) induces differentiation and is cytotoxic through promotion of apoptosis in acute myeloid leukaemic cell lines U937, HL60 and Kasumi-1[1]. Apoptosis Analysis[1] Cell Line: HL60 and Kasumi-1 cells Concentration: 150 nM, 300 nM, 500 nM, 1 μM Incubation Time: 72 h Result: Induced a substantial degree of apoptosis in both HL60 and Kasumi-1 cells.
In Vivo	MI-192 (40 mg/kg; i.p; once a day; for 3 days) shows the neuroprotective activity in the mouse brain subjected to photothrombotic stroke[2]. Animal Model: Adult male outbred mice CD-1 (20-25 g) with photothrombotic stroke (PTS)[2] Dosage: 40 mg/kg Administration: i.p; once a day; for 3 days Result: Reduced the volume of the PTS-induced infarction core in the mouse brain, partly restored the functional symmetry in the forelimb use, decreased the level of PTS-induced apoptosis and acetylation of α-tubulin characteristic for stable microtubules, and increased the expression of GAP-43 in the cerebral cortex of the damaged hemisphere.
References	[1]. Marjorie Boissinot, et al. Induction of differentiation and apoptosis in leukaemic cell lines by the novel benzamide family histone deacetylase 2 and 3 inhibitor MI-192. Leuk Res. 2012 Oct;36(10):1304-10. [2]. S V Demyanenko, et al. The Neuroprotective Effect of the HDAC2/3 Inhibitor MI192 on the Penumbra After Photothrombotic Stroke in the Mouse Brain. Mol Neurobiol. 2020 Jan;57(1):239-248.

Density	1.3±0.1 g/cm3
Boiling Point	565.0±50.0 °C at 760 mmHg
Molecular Formula	C₂₄H₂₁N₃O₂
Molecular Weight	383.44
Flash Point	295.5±30.1 °C
Exact Mass	383.163391
LogP	2.19
Vapour Pressure	0.0±1.5 mmHg at 25°C
Index of Refraction	1.693
Storage condition	2-8°C

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