908027-55-4

908027-55-4 structure

Name: MI 219
Chemical Name: (2'R,3S,4'R,5'R)-6-Chloro-4'-(3-chlorophenyl)-N-[(3S)-3,4-dihydroxybutyl]-2'-(2,2-dimethylpropyl)-5-fluoro-2-oxo-1,2-dihydrospiro[indole-3,3'-pyrrolidine]-5'-carboxamide
CAS Number: 908027-55-4
Molecular Formula: C₂₇H₃₂Cl₂FN₃O₄
Molecular Weight: 552.465
Create Date: 2020-01-11 18:04:49
Modify Date: 2024-02-04 18:27:05
MI 219 is a potent, specific MDM2-p53 inhibitor with Ki of 5 nM, >10,000-fold selective for MDM2 over MDMX; disrupts the MDM2-p53 interaction and activates the p53 pathway in cells with wild-type p53, which leads to induction of cell cycle arrest in all cells and selective apoptosis in tumor cells; inhibits tumor growth in mouse xenograft models.

Name	(2'R,3S,4'R,5'R)-6-Chloro-4'-(3-chlorophenyl)-N-[(3S)-3,4-dihydroxybutyl]-2'-(2,2-dimethylpropyl)-5-fluoro-2-oxo-1,2-dihydrospiro[indole-3,3'-pyrrolidine]-5'-carboxamide
Synonyms	Spiro[3H-indole-3,3'-pyrrolidine]-5'-carboxamide, 6-chloro-4'-(3-chlorophenyl)-N-[(3S)-3,4-dihydroxybutyl]-2'-(2,2-dimethylpropyl)-5-fluoro-1,2-dihydro-2-oxo-, (2'R,3S,4'R,5'R)- (2'R,3S,4'R,5'R)-6-Chloro-4'-(3-chlorophenyl)-N-[(3S)-3,4-dihydroxybutyl]-2'-(2,2-dimethylpropyl)-5-fluoro-2-oxo-1,2-dihydrospiro[indole-3,3'-pyrrolidine]-5'-carboxamide

Description	MI 219 is a potent, specific MDM2-p53 inhibitor with Ki of 5 nM, >10,000-fold selective for MDM2 over MDMX; disrupts the MDM2-p53 interaction and activates the p53 pathway in cells with wild-type p53, which leads to induction of cell cycle arrest in all cells and selective apoptosis in tumor cells; inhibits tumor growth in mouse xenograft models.
References	References 1. Shangary S, et al. Proc Natl Acad Sci U S A. 2008 Mar 11;105(10):3933-8. 2. Peterson LF, et al. Leukemia. 2011 May;25(5):761-9. 3. Feng FY, et al. Neoplasia. 2016 Apr;18(4):213-22. View Related Products by Target MDM2-p53