MI-1061
Modify Date: 2024-01-09 23:13:22
MI-1061 structure
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Common Name | MI-1061 | ||
|---|---|---|---|---|
| CAS Number | 1410737-34-6 | Molecular Weight | 582.45 | |
| Density | N/A | Boiling Point | N/A | |
| Molecular Formula | C30H26Cl2FN3O4 | Melting Point | N/A | |
| MSDS | N/A | Flash Point | N/A | |
Use of MI-1061MI-1061 is a potent, orally bioavailable, and chemically stable MDM2 (MDM2-p53 interaction) inhibitor (IC50=4.4 nM; Ki=0.16 nM). MI-1061 potently activates p53, induces apoptosis, and has anti-tumor activity[1]. |
| Name | MI-1061 |
|---|
| Description | MI-1061 is a potent, orally bioavailable, and chemically stable MDM2 (MDM2-p53 interaction) inhibitor (IC50=4.4 nM; Ki=0.16 nM). MI-1061 potently activates p53, induces apoptosis, and has anti-tumor activity[1]. |
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| Related Catalog | |
| Target |
IC50: 4.4 nM (MDM2)[1] Ki: 0.16 nM (MDM2) |
| In Vitro | MI-1061 achieves IC50=100 and 250 nM in the SJSA-1 and HCT-116 p53+/+ cell lines, respectively, and has IC50>10000 nM in the p53 knockout cell line HCT-116 p53–/–cell line[1]. |
| In Vivo | MI-1061 is capable of achieving tumor regression in the SJSA-1 xenograft tumor model in mice with oral administration[1]. |
| References |
| Molecular Formula | C30H26Cl2FN3O4 |
|---|---|
| Molecular Weight | 582.45 |
| InChIKey | BIDSEXPFIMKDMF-LOLKONATSA-N |
| SMILES | O=C(O)c1ccc(NC(=O)C2NC3(CCCCC3)C3(C(=O)Nc4cc(Cl)ccc43)C2c2cccc(Cl)c2F)cc1 |